PMID- 20098297
OWN - NLM
STAT- MEDLINE
DCOM- 20100727
LR  - 20201106
IS  - 1533-0311 (Electronic)
IS  - 0193-1091 (Linking)
VI  - 32
IP  - 3
DP  - 2010 May
TI  - p63 Immunohistochemistry is a useful adjunct in distinguishing sclerosing 
      cutaneous tumors.
PG  - 257-261
LID - 10.1097/DAD.0b013e3181b7fc76 [doi]
AB  - Cutaneous sclerosing epithelial neoplasms are often difficult to diagnose. Though 
      various immunohistochemical markers have proved useful, some cases remain a 
      diagnostic challenge. We aimed to assess the utility of p63 immunohistochemical 
      staining in distinguishing microcystic adnexal carcinoma (MAC) from sclerosing 
      basal cell carcinoma (SBCC) and desmoplastic trichoepithelioma (DTE). Biopsy 
      samples from 20 SBCC, 10 DTE, and 5 MAC were examined after immunohistochemical 
      staining with p63. Although all adnexal tumors examined demonstrated p63 
      expression, the pattern of staining was strikingly different in MAC when compared 
      with other tumor types. MAC exhibited a scattered pattern with p63-positive cells 
      around the periphery of tumor nests and minimal staining within the center of the 
      tumor islands. This pattern was more pronounced at increased depth of 
      infiltration into the dermis. A robust and consistent diffuse pattern of staining 
      with p63 was observed in all SBCCs and DTEs. We believe this pattern reflects the 
      multi-differentiation pathway of MAC, with eccrine/sebaceous differentiation 
      occurring at deeper levels of the dermis. The different staining patterns of MACs 
      compared with DTEs and SBCCs can thus serve asa useful diagnostic adjunct in 
      difficult lesions.
FAU - Vidal, Claudia I
AU  - Vidal CI
AD  - From the *Division of Dermatopathology; daggerDepartments of Pathology; and double daggerOncologic 
      Sciences, Mount Sinai Medical Center, NY.
FAU - Goldberg, Matthew
AU  - Goldberg M
FAU - Burstein, David E
AU  - Burstein DE
FAU - Emanuel, Henry J
AU  - Emanuel HJ
FAU - Emanuel, Patrick O
AU  - Emanuel PO
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Am J Dermatopathol
JT  - The American Journal of dermatopathology
JID - 7911005
RN  - 0 (Biomarkers, Tumor)
RN  - 0 (TP63 protein, human)
RN  - 0 (Trans-Activators)
RN  - 0 (Transcription Factors)
RN  - 0 (Tumor Suppressor Proteins)
SB  - IM
MH  - Biomarkers, Tumor/*analysis
MH  - Carcinoma, Basal Cell/chemistry/*diagnosis
MH  - Carcinoma, Skin Appendage/chemistry/*diagnosis
MH  - Humans
MH  - Immunoenzyme Techniques
MH  - Retrospective Studies
MH  - Skin Neoplasms/chemistry/*diagnosis
MH  - Trans-Activators/*analysis
MH  - Transcription Factors
MH  - Tumor Suppressor Proteins/*analysis
EDAT- 2010/01/26 06:00
MHDA- 2010/07/28 06:00
CRDT- 2010/01/26 06:00
PHST- 2010/01/26 06:00 [entrez]
PHST- 2010/01/26 06:00 [pubmed]
PHST- 2010/07/28 06:00 [medline]
AID - 10.1097/DAD.0b013e3181b7fc76 [doi]
PST - ppublish
SO  - Am J Dermatopathol. 2010 May;32(3):257-261. doi: 10.1097/DAD.0b013e3181b7fc76.