PMID- 20098632
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20211020
IS  - 1937-9080 (Print)
IS  - 1937-9080 (Electronic)
IS  - 1937-9080 (Linking)
VI  - 1
IP  - 2
DP  - 2009 Apr 1
TI  - Regulation of Microvascular Function by Adipose Tissue in Obesity and Type 2 
      Diabetes: Evidence of an Adipose-Vascular Loop.
PG  - 133
AB  - In recent years, the general concept has emerged that chronic low-grade 
      inflammation is the condition linking excessive development of adipose tissue and 
      obesity-associated pathologies such as type 2 diabetes and cardiovascular 
      diseases. Obesity and type 2 diabetes are characterized by a diminished 
      production of protective factors such as adiponectin and increased detrimental 
      adipocytokines such as leptin, resistin, interleukin-6 (IL-6), tumor necrosis 
      factor-alpha (TNFalpha), and monocyte chemoattractant protein-1 (MCP-1) by adipose 
      tissue. Moreover, the evidence that the growth of the fat mass is associated with 
      an accumulation of adipose tissue macrophages and T-lymphocytes has raised the 
      hypothesis that the development of an inflammatory process within the growing fat 
      mass is a primary event involved in the genesis of systemic metabolic and 
      vascular alterations. This crosstalk of adipocyte, macrophage, lymphocyte, 
      endothelial cells, and vascular smooth muscle cells contribute to the production 
      of various cytokines, chemokines, and hormone-like factors, which actively 
      participate in the regulation of vascular function by an endocrine and/or 
      paracrine pattern. Thus, the signaling from perivascular adipose to the blood 
      vessels is emerging as a potential therapeutic target for obesity and 
      diabetes-associated vascular dysfunction.
FAU - Zhang, Hanrui
AU  - Zhang H
AD  - Departments of Internal Medicine, Medical Pharmacology & Physiology and 
      Nutritional Sciences, Dalton Cardiovascular Research Center, University of 
      Missouri-Columbia, Columbia, MO 65211.
FAU - Zhang, Cuihua
AU  - Zhang C
LA  - eng
GR  - R01 HL077566-01A2/HL/NHLBI NIH HHS/United States
GR  - R01 HL077566/HL/NHLBI NIH HHS/United States
GR  - R01 HL077566-03/HL/NHLBI NIH HHS/United States
GR  - R01 HL085119-01A1/HL/NHLBI NIH HHS/United States
GR  - R01 HL085119-03/HL/NHLBI NIH HHS/United States
GR  - R01 HL085119/HL/NHLBI NIH HHS/United States
GR  - R01 HL077566-02/HL/NHLBI NIH HHS/United States
GR  - R01 HL085119-04/HL/NHLBI NIH HHS/United States
GR  - R01 HL085119-02/HL/NHLBI NIH HHS/United States
PT  - Journal Article
PL  - United States
TA  - Am J Biomed Sci
JT  - American journal of biomedical sciences
JID - 101515147
PMC - PMC2809393
MID - NIHMS99789
EDAT- 2010/01/26 06:00
MHDA- 2010/01/26 06:01
PMCR- 2010/01/21
CRDT- 2010/01/26 06:00
PHST- 2010/01/26 06:00 [entrez]
PHST- 2010/01/26 06:00 [pubmed]
PHST- 2010/01/26 06:01 [medline]
PHST- 2010/01/21 00:00 [pmc-release]
AID - 10.5099/aj090200133 [doi]
PST - ppublish
SO  - Am J Biomed Sci. 2009 Apr 1;1(2):133. doi: 10.5099/aj090200133.