PMID- 20099492
OWN - NLM
STAT- MEDLINE
DCOM- 20100413
LR  - 20200929
IS  - 0392-2936 (Print)
IS  - 0392-2936 (Linking)
VI  - 30
IP  - 6
DP  - 2009
TI  - Breast cancer patients with micrometastases in sentinel lymph nodes: differences 
      considering additional metastatic lymph nodes.
PG  - 631-4
AB  - AIMS: Characterization of breast cancer patients with micrometastases in sentinel 
      lymph node (SLN) and establish differences between micrometastatic breast cancers 
      with additional metastatic lymph nodes (LNS) versus no other lymph node invasion. 
      METHODS: Analysis of 30 breast cancers, N1mi or pN0(i+), diagnosed and treated in 
      our department from July 2000 to July 2008. RESULTS: Micrometastases in SLNs were 
      found in 30 patients. Complete axillary dissection revealed other metastatic LNs 
      in 24%. Concerning breast cancers with additional LN invasion versus no other LN 
      invasion, tumors located in the superior-external quadrant were more frequent in 
      the former group. Other characteristics as clinical presentation, histological 
      subtype, focality, cytonuclear grade, hormone receptors and Her2 expression were 
      not significantly different in either group. Regarding SLN invasion, the presence 
      of at least two micrometastatic foci were significantly more relevant in patients 
      with other metastatic LN invasion (p < 0.01). Micrometastases diagnosed only 
      after immunohistochemistry (IHC) were exclusively found in patients without other 
      LN invasion, reaching statistical significance (p < 0.05). CONCLUSIONS: Complete 
      axillary dissection revealed additional LN invasion in 24% of patients with 
      micrometastases in the SLN. Tumors with additional LN invasion were more 
      frequently found in the superior external quadrant and SLNs harbored at least two 
      micrometastatic foci. Micrometastases diagnosed exclusively by IHC techniques 
      were more relevant in cases without additional lymph node invasion.
FAU - Carvalho, M J
AU  - Carvalho MJ
AD  - Department of Gynaecology, University Hospital of Coimbra, Portugal. 
      mariaj.carvalho@sapo.pt
FAU - Dias, M F
AU  - Dias MF
FAU - Silva, T S
AU  - Silva TS
FAU - Custodio, S
AU  - Custodio S
FAU - de Oliveira, C F
AU  - de Oliveira CF
LA  - eng
PT  - Journal Article
PL  - Singapore
TA  - Eur J Gynaecol Oncol
JT  - European journal of gynaecological oncology
JID - 8100357
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Breast Neoplasms/*pathology
MH  - Female
MH  - Humans
MH  - Lymphatic Metastasis/diagnosis/pathology
MH  - Middle Aged
MH  - *Sentinel Lymph Node Biopsy
EDAT- 2010/01/27 06:00
MHDA- 2010/04/14 06:00
CRDT- 2010/01/27 06:00
PHST- 2010/01/27 06:00 [entrez]
PHST- 2010/01/27 06:00 [pubmed]
PHST- 2010/04/14 06:00 [medline]
PST - ppublish
SO  - Eur J Gynaecol Oncol. 2009;30(6):631-4.