PMID- 20100023
OWN - NLM
STAT- MEDLINE
DCOM- 20100222
LR  - 20220409
IS  - 1532-4303 (Electronic)
IS  - 0277-0903 (Linking)
VI  - 47
IP  - 1
DP  - 2010 Feb
TI  - Saliva and serum eosinophil cationic protein in asthmatic children and 
      adolescents with and without allergic sensitization.
PG  - 61-5
LID - 10.3109/02770900903350499 [doi]
AB  - Saliva eosinophil cationic protein (ECP) is higher in asthmatic adults than in 
      healthy ones. However, its relationship with asthma severity, other atopic 
      conditions and allergic sensitization have not been reported. Saliva collection 
      is painless, readily acceptable to children and parents, and can be a potentially 
      useful body fluid to measure asthma biomarkers. We recruited 102 
      physician-diagnosed young asthmatic subjects from outpatient clinics with change 
      in FEV(1) > or = 12% with inhaled salbutamol and collected data on asthma 
      severity, concurrent allergic rhinitis (AR) and atopic dermatitis (AD), and 
      medication used (bronchodilator and corticosteroid). We measured whole saliva and 
      serum ECP and performed skin prick tests (SPT) for three dust mites 
      (Dermatophagoides pteronyssisinus, Dermatophagoides farinae and Blomia 
      tropicalis) and two cockroaches (Periplaneta americana and Blatella germanica). 
      Median salivary ECP was 84.6 microg/l (inter-quartile range [IQR]: 40.9-147.9) 
      and median serum ECP was 14.7 microg/l (IQR: 6.4-32.1). Serum ECP was only higher 
      in children whose sleep was disturbed by asthma in the past year than those who 
      were not (geometric mean [GM]: 18.9 vs. 11.1 microg/l, relative mean difference 
      [RMD]: 1.71 [95%CI: 1.09-2.69]). Serum ECP was increased among asthmatic children 
      on inhaled corticosteroid than those not using them (GM: 15.6 vs. 8.1 microg/l, 
      RMD: 1.93 [95%CI: 1.11-3.39]). Salivary ECP was not associated with asthma 
      severity, concurrence of atopic conditions, medications used, or any SPT 
      parameter. Saliva ECP did not correlate with serum ECP (r(s) = 0.032, p = 0.790). 
      Salivary and serum ECP did not correlate with wheal size for any skin prick test.
FAU - Koh, Gerald Choon-Huat
AU  - Koh GC
AD  - Department of Epidemiology and Public Health, Yong Loo Lin School of Medicine, 
      National University of Singapore, National University Health System, Singapore 
      117597. ephkohch@nus.edu.sg
FAU - Shek, Lynette Pei-Chi
AU  - Shek LP
FAU - Kee, Janine
AU  - Kee J
FAU - Wee, Andrew
AU  - Wee A
FAU - Ng, Vivian
AU  - Ng V
FAU - Koh, David
AU  - Koh D
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - J Asthma
JT  - The Journal of asthma : official journal of the Association for the Care of 
      Asthma
JID - 8106454
RN  - 0 (Adrenal Cortex Hormones)
RN  - 0 (Allergens)
RN  - EC 3.1.27.- (Eosinophil Cationic Protein)
RN  - EC 3.1.27.- (RNASE3 protein, human)
SB  - IM
MH  - Adolescent
MH  - Adrenal Cortex Hormones/administration & dosage/therapeutic use
MH  - Adult
MH  - Allergens/immunology
MH  - Animals
MH  - Asthma/*blood/complications/drug therapy/*metabolism
MH  - Child
MH  - Child, Preschool
MH  - Cockroaches/immunology
MH  - Dermatitis, Atopic/complications/epidemiology
MH  - Eosinophil Cationic Protein/*blood/*metabolism
MH  - Female
MH  - Humans
MH  - Hypersensitivity/diagnosis/immunology/*metabolism
MH  - Male
MH  - Pyroglyphidae/immunology
MH  - Respiratory Hypersensitivity/complications/epidemiology
MH  - Saliva/*metabolism
MH  - Singapore/epidemiology
MH  - Skin Tests
MH  - Sleep Wake Disorders/etiology/metabolism
MH  - Young Adult
EDAT- 2010/01/27 06:00
MHDA- 2010/02/23 06:00
CRDT- 2010/01/27 06:00
PHST- 2010/01/27 06:00 [entrez]
PHST- 2010/01/27 06:00 [pubmed]
PHST- 2010/02/23 06:00 [medline]
AID - 10.3109/02770900903350499 [doi]
PST - ppublish
SO  - J Asthma. 2010 Feb;47(1):61-5. doi: 10.3109/02770900903350499.