PMID- 20100030
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20100222
LR  - 20100223
IS  - 1532-4303 (Electronic)
IS  - 0277-0903 (Linking)
VI  - 47
IP  - 1
DP  - 2010 Feb
TI  - Increased plasma reactive oxidant levels and their relationship to blood cells, 
      total IgE, and allergen-specific IgE levels in asthmatic children.
PG  - 106-11
LID - 10.3109/02770900903435964 [doi]
AB  - Asthma is a disorder characterized by inflammation of the airways. Oxidative 
      stress may play a role in the pathophysiology of several diseases including 
      asthma. Characterizing biomarkers of oxidative stress in the context of other 
      systemic measures of immune function or inflammation could provide insight 
      regarding underlying mechanisms inducing asthma. We evaluated whether oxidative 
      stress in the form of plasma reactive oxidants differs between asthmatic and 
      non-asthmatic children and elucidate relationships between plasma reactive 
      oxidants and other asthma-related immunological markers. Plasma reactive 
      oxidants, white blood cell counts, total serum immunoglobulin E(IgE), and a 
      multi-allergen-specific IgE screen were measured in 74 asthmatic and 74 
      non-asthmatic children(9 to 13 years of age) from the Detroit, Michigan area. 
      Plasma reactive oxidants were measured using a lucigenin-based chemiluminescence 
      assay. Plasma reactive oxidants, eosinophils, and neutrophils(absolute counts and 
      percent of total white blood cell counts), total IgE, and allergen-specific IgE 
      levels were elevated in asthmatics after adjusting for age, gender, and 
      ethnicity. IgE(total or allergen-specific), eosinophils and neutrophils were not 
      significantly associated with plasma reactive oxidant levels. The association 
      between plasma reactive oxidants and asthma status was similar when eosinophils, 
      neutrophils, total IgE, or allergen-specific IgE were included as possible 
      confounders in multivariate logistic regression models. In conclusion, plasma 
      reactive oxidants are elevated in asthmatics and appear to be an independent 
      predictor of asthma status. Measurement of plasma reactive oxidants may be a 
      useful adjunct diagnostic tool and potential mechanistic indicator relevant to 
      the study of asthma and asthma exacerbation.
FAU - Heidenfelder, Brooke
AU  - Heidenfelder B
AD  - US Environmental Protection Agency (EPA), Human Studies Division, Research 
      Triangle Park, North Carolina, USA.
FAU - Johnson, Markey
AU  - Johnson M
FAU - Hudgens, Edward
AU  - Hudgens E
FAU - Inmon, Jefferson
AU  - Inmon J
FAU - Hamilton, Robert G
AU  - Hamilton RG
FAU - Neas, Lucas
AU  - Neas L
FAU - Gallagher, Jane E
AU  - Gallagher JE
LA  - eng
PT  - Journal Article
PL  - England
TA  - J Asthma
JT  - The Journal of asthma : official journal of the Association for the Care of 
      Asthma
JID - 8106454
RPF - J Asthma. 2009 Sep;46(7):687-91. PMID: 19728206
EDAT- 2010/01/27 06:00
MHDA- 2010/02/23 06:00
CRDT- 2010/01/27 06:00
PHST- 2010/01/27 06:00 [entrez]
PHST- 2010/01/27 06:00 [pubmed]
PHST- 2010/02/23 06:00 [medline]
AID - 10.3109/02770900903435964 [doi]
PST - ppublish
SO  - J Asthma. 2010 Feb;47(1):106-11. doi: 10.3109/02770900903435964.