PMID- 2010057
OWN - NLM
STAT- MEDLINE
DCOM- 19910507
LR  - 20221115
IS  - 0892-6638 (Print)
IS  - 0892-6638 (Linking)
VI  - 5
IP  - 7
DP  - 1991 Apr
TI  - Transcriptional control by nuclear receptors.
PG  - 2044-51
AB  - Gene regulation by steroid hormones is accomplished by a variety of different 
      mechanisms leading to induction or repression of particular genes. These 
      mechanisms are all mediated by a single class of intracellular hormone receptors, 
      which in the unliganded state are maintained in an inactive form by association 
      with other cellular proteins, including hsp90. Induction of the mouse mammary 
      tumor virus (MMTV) requires binding of the hormone receptor to a 
      hormone-responsive element (HRE) that is precisely organized in a phased 
      nucleosome. After receptor binding, changes in chromatin structure are detected 
      that correlate with binding of transcription factors, including nuclear factor I, 
      to the MMTV promoter. However, although nuclear factor I acts as a basal 
      transcription factor on the MMTV promoter it does not cooperate with the hormone 
      receptors in terms of binding to free DNA, and mutation of the nuclear factor I 
      binding site does not eliminate hormonal stimulation. This residual induction is 
      mediated by octamer motifs upstream of the TATA box that bind the ubiquitous 
      transcription factor OTF-1. Mutation of these octamer motifs does not influence 
      basal transcription in vitro, but completely abolishes the stimulatory effect of 
      progesterone receptor. Glucocorticoids also inhibit expression of many genes. The 
      effect on the gene for the alpha-subunit of chorionic gonadotropin is due to DNA 
      binding competition between the receptor and the protein mediating cAMP 
      induction, whereas repression of the collagenase gene involves an interaction of 
      the receptor with components of the AP1 complex, Jun and Fos.
FAU - Beato, M
AU  - Beato M
AD  - Institut fur Molekularbiologie und Tumorforschung, I.M.T., Marburg, Germany.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - United States
TA  - FASEB J
JT  - FASEB journal : official publication of the Federation of American Societies for 
      Experimental Biology
JID - 8804484
RN  - 0 (Receptors, Steroid)
RN  - 0 (Transcription Factors)
RN  - 9007-49-2 (DNA)
SB  - IM
MH  - Amino Acid Sequence
MH  - Binding, Competitive
MH  - DNA/genetics/metabolism
MH  - Kinetics
MH  - Molecular Sequence Data
MH  - Nucleic Acid Conformation
MH  - Receptors, Steroid/*physiology
MH  - Transcription Factors/physiology
MH  - *Transcription, Genetic
MH  - Zinc Fingers/genetics
RF  - 42
EDAT- 1991/04/01 00:00
MHDA- 1991/04/01 00:01
CRDT- 1991/04/01 00:00
PHST- 1991/04/01 00:00 [pubmed]
PHST- 1991/04/01 00:01 [medline]
PHST- 1991/04/01 00:00 [entrez]
AID - 10.1096/fasebj.5.7.2010057 [doi]
PST - ppublish
SO  - FASEB J. 1991 Apr;5(7):2044-51. doi: 10.1096/fasebj.5.7.2010057.