PMID- 20101024
OWN - NLM
STAT- MEDLINE
DCOM- 20100413
LR  - 20220224
IS  - 1528-0020 (Electronic)
IS  - 0006-4971 (Linking)
VI  - 115
IP  - 12
DP  - 2010 Mar 25
TI  - The MHC class Ib protein ULBP1 is a nonredundant determinant of leukemia/lymphoma 
      susceptibility to gammadelta T-cell cytotoxicity.
PG  - 2407-11
LID - 10.1182/blood-2009-08-237123 [doi]
AB  - On the path to successful immunotherapy of hematopoietic tumors, gammadelta T 
      cells offer great promise because of their human leukocyte antigen 
      (HLA)-unrestricted targeting of a wide variety of leukemias/lymphomas. However, 
      the molecular mechanisms underlying lymphoma recognition by gammadelta T cells 
      remain unclear. Here we show that the expression levels of UL16-binding protein 1 
      (ULBP1) determine lymphoma susceptibility to gammadelta T cell-mediated 
      cytolysis. Consistent with this, blockade of NKG2D, the receptor for ULBP1 
      expressed on all Vgamma9(+) T cells, significantly inhibits lymphoma cell 
      killing. Specific loss-of-function studies demonstrate that the role of ULBP1 is 
      nonredundant, highlighting a thus far unique physiologic relevance for tumor 
      recognition by gammadelta T cells. Importantly, we observed a very wide spectrum 
      of ULBP1 expression levels in primary biopsies obtained from lymphoma and 
      leukemia patients. We suggest this will impact on the responsiveness to 
      gammadelta T cell-based immunotherapy, and therefore propose ULBP1 to be used as 
      a leukemia/lymphoma biomarker in upcoming clinical trials.
FAU - Lanca, Telma
AU  - Lanca T
AD  - Instituto de Medicina Molecular, Faculdade de Medicina da Universidade de Lisboa, 
      1649-028 Lisboa, Portugal.
FAU - Correia, Daniel V
AU  - Correia DV
FAU - Moita, Catarina F
AU  - Moita CF
FAU - Raquel, Helena
AU  - Raquel H
FAU - Neves-Costa, Ana
AU  - Neves-Costa A
FAU - Ferreira, Cristina
AU  - Ferreira C
FAU - Ramalho, Jose S
AU  - Ramalho JS
FAU - Barata, Joao T
AU  - Barata JT
FAU - Moita, Luis F
AU  - Moita LF
FAU - Gomes, Anita Q
AU  - Gomes AQ
FAU - Silva-Santos, Bruno
AU  - Silva-Santos B
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20100125
PL  - United States
TA  - Blood
JT  - Blood
JID - 7603509
RN  - 0 (Biomarkers, Tumor)
RN  - 0 (GPI-Linked Proteins)
RN  - 0 (Intracellular Signaling Peptides and Proteins)
RN  - 0 (Membrane Proteins)
RN  - 0 (RNA, Small Interfering)
RN  - 0 (Receptors, Antigen, T-Cell, gamma-delta)
RN  - 0 (ULBP1 protein, human)
SB  - IM
MH  - Biomarkers, Tumor/immunology/*metabolism
MH  - Biopsy
MH  - Cell Line, Tumor
MH  - Clinical Trials as Topic/methods
MH  - GPI-Linked Proteins
MH  - Humans
MH  - Immunotherapy/methods
MH  - Intracellular Signaling Peptides and Proteins/genetics/*metabolism
MH  - Leukemia, B-Cell/metabolism/pathology/therapy
MH  - Leukemia, T-Cell/metabolism/pathology/therapy
MH  - Lymphoma/metabolism/pathology/therapy
MH  - Membrane Proteins/genetics/*metabolism
MH  - Precursor Cell Lymphoblastic Leukemia-Lymphoma/*metabolism/pathology/therapy
MH  - RNA, Small Interfering
MH  - Receptors, Antigen, T-Cell, gamma-delta/*metabolism
MH  - T-Lymphocytes, Cytotoxic/immunology/*metabolism
EDAT- 2010/01/27 06:00
MHDA- 2010/04/14 06:00
CRDT- 2010/01/27 06:00
PHST- 2010/01/27 06:00 [entrez]
PHST- 2010/01/27 06:00 [pubmed]
PHST- 2010/04/14 06:00 [medline]
AID - S0006-4971(20)56591-9 [pii]
AID - 10.1182/blood-2009-08-237123 [doi]
PST - ppublish
SO  - Blood. 2010 Mar 25;115(12):2407-11. doi: 10.1182/blood-2009-08-237123. Epub 2010 
      Jan 25.