PMID- 20102061
OWN - NLM
STAT- MEDLINE
DCOM- 20100318
LR  - 20100127
IS  - 0350-6134 (Print)
IS  - 0350-6134 (Linking)
VI  - 33
IP  - 4
DP  - 2009 Dec
TI  - Myasthenia gravis patients with anti-MuSK antibodies.
PG  - 1151-4
AB  - In myasthenia gravis (MG) patients without detectable anti-acetylcholine receptor 
      (anti-AChR) antibody, referred to as seronegative myasthenia gravis patients, 
      there is a variable proportion of patients with antibodies against the 
      muscle-specific kinase (MuSK). MuSK antibodies were found in 8 (29.6%) of our 27 
      patients with generalized MG without anti-AChR antibodies. All these patients 
      were female. The age at the onset ranged from 22 to 38 years. All patients had 
      ocular and bulbar symptoms, and two patients also had generalized limb weakness. 
      Two patients had pure ocular symptoms for 7 or 8 years before the development of 
      bulbar symptoms. All anti-MuSK positive patients were treated with 
      immunosuppressive drugs, three received plasmapheresis and one patient required 
      mechanical ventilation. Our results are consistent with other literature reports.
FAU - Zagar, Marija
AU  - Zagar M
AD  - Department of Neurology, University Hospital Center Zagreb, Zagreb, Croatia. 
      mzagar2000@yahoo.com
FAU - Vranjes, Davorka
AU  - Vranjes D
FAU - Sostarko, Marija
AU  - Sostarko M
FAU - Vogrinc, Zeljka
AU  - Vogrinc Z
FAU - Bilic, Ervina
AU  - Bilic E
FAU - Trbojevic Cepe, Milica
AU  - Trbojevic Cepe M
LA  - eng
PT  - Case Reports
PT  - Journal Article
PL  - Croatia
TA  - Coll Antropol
JT  - Collegium antropologicum
JID - 8003354
RN  - 0 (Autoantibodies)
RN  - 0 (Receptors, Cholinergic)
RN  - EC 2.7.10.1 (MUSK protein, human)
RN  - EC 2.7.10.1 (Receptor Protein-Tyrosine Kinases)
SB  - IM
MH  - Adult
MH  - Autoantibodies/*blood
MH  - Croatia
MH  - Female
MH  - Humans
MH  - Myasthenia Gravis/*immunology
MH  - Receptor Protein-Tyrosine Kinases/*immunology
MH  - Receptors, Cholinergic/*immunology
EDAT- 2010/01/28 06:00
MHDA- 2010/03/20 06:00
CRDT- 2010/01/28 06:00
PHST- 2010/01/28 06:00 [entrez]
PHST- 2010/01/28 06:00 [pubmed]
PHST- 2010/03/20 06:00 [medline]
PST - ppublish
SO  - Coll Antropol. 2009 Dec;33(4):1151-4.