PMID- 20102630
OWN - NLM
STAT- MEDLINE
DCOM- 20100510
LR  - 20240322
IS  - 1471-2334 (Electronic)
IS  - 1471-2334 (Linking)
VI  - 10
DP  - 2010 Jan 26
TI  - Association of HIV infection with distribution and viral load of HPV types in 
      Kenya: a survey with 820 female sex workers.
PG  - 18
LID - 10.1186/1471-2334-10-18 [doi]
AB  - BACKGROUND: Human papillomavirus (HPV) and HIV are each responsible for a 
      considerable burden of disease. Interactions between these infections pose 
      substantial public health challenges, especially where HIV prevalence is high and 
      HPV vaccine coverage low. METHODS: Between July 2005 and January 2006, a 
      cross-sectional community-based survey in Mombasa, Kenya, enrolled female sex 
      workers using snowball sampling. After interview and a gynaecological 
      examination, blood and cervical cytology samples were taken. Quantitative 
      real-time PCR detected HPV types and viral load measures. Prevalence of high-risk 
      HPV was compared between HIV-infected and -uninfected women, and in women with 
      abnormal cervical cytology, measured using conventional Pap smears. RESULTS: 
      Median age of the 820 participants was 28 years (inter-quartile range [IQR] = 
      24-36 years). One third of women were HIV infected (283/803; 35.2%) and these 
      women were y more likely to have abnormal cervical cytology than HIV-negative 
      women (27%, 73/269, versus 8%, 42/503; P < 0.001). Of HIV-infected women, 73.3% 
      had high-risk HPV (200/273) and 35.5% had HPV 16 and/or 18 (97/273). 
      Corresponding figures for HIV-negative women were 45.5% (229/503) and 15.7% 
      (79/503). After adjusting for age, number of children and condom use, high-risk 
      HPV was 3.6 fold more common in HIV-infected women (95%CI = 2.6-5.1). Prevalence 
      of all 15 of the high-risk HPV types measured was higher among HIV-infected 
      women, between 1.4 and 5.5 fold. Median total HPV viral load was 881 copies/cell 
      in HIV-infected women (IQR = 33-12,110 copies/cell) and 48 copies/cell in 
      HIV-uninfected women (IQR = 6-756 copies/cell; P < 0.001). HPV 16 and/or HPV 18 
      were identified in 42.7% of LSIL (32/75) and 42.3% of HSIL (11/26) lesions (P = 
      0.98). High-risk HPV types other than 16 and 18 were common in LSIL (74.7%; 
      56/75) and HSIL (84.6%; 22/26); even higher among HIV-infected women. 
      CONCLUSIONS: HIV-infected sex workers had almost four-fold higher prevalence of 
      high-risk HPV, raised viral load and more precancerous lesions. HPV 16 and HPV 
      18, preventable with current vaccines, were associated with cervical disease, 
      though other high-risk types were commoner. HIV-infected sex workers likely 
      contribute disproportionately to HPV transmission dynamics in the general 
      population. Current efforts to prevent HIV and HPV are inadequate. New 
      interventions are required and improved implementation of existing strategies.
FAU - Luchters, Stanley M F
AU  - Luchters SM
AD  - International Centre for Reproductive Health (ICRH), Ghent University, Belgium.
FAU - Vanden Broeck, Davy
AU  - Vanden Broeck D
FAU - Chersich, Matthew F
AU  - Chersich MF
FAU - Nel, Annalene
AU  - Nel A
FAU - Delva, Wim
AU  - Delva W
FAU - Mandaliya, Kishor
AU  - Mandaliya K
FAU - Depuydt, Christophe E
AU  - Depuydt CE
FAU - Claeys, Patricia
AU  - Claeys P
FAU - Bogers, John-Paul
AU  - Bogers JP
FAU - Temmerman, Marleen
AU  - Temmerman M
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20100126
PL  - England
TA  - BMC Infect Dis
JT  - BMC infectious diseases
JID - 100968551
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Cervix Uteri/pathology
MH  - Comorbidity
MH  - Cross-Sectional Studies
MH  - Female
MH  - HIV Infections/*complications/*epidemiology
MH  - Humans
MH  - Kenya/epidemiology
MH  - Middle Aged
MH  - Papillomaviridae/classification/genetics/*isolation & purification
MH  - Papillomavirus Infections/*complications/*epidemiology/virology
MH  - Prevalence
MH  - *Sex Work
MH  - Uterine Cervical Neoplasms/pathology/virology
MH  - *Viral Load
MH  - Young Adult
PMC - PMC2845133
EDAT- 2010/01/28 06:00
MHDA- 2010/05/11 06:00
PMCR- 2010/01/26
CRDT- 2010/01/28 06:00
PHST- 2009/09/23 00:00 [received]
PHST- 2010/01/26 00:00 [accepted]
PHST- 2010/01/28 06:00 [entrez]
PHST- 2010/01/28 06:00 [pubmed]
PHST- 2010/05/11 06:00 [medline]
PHST- 2010/01/26 00:00 [pmc-release]
AID - 1471-2334-10-18 [pii]
AID - 10.1186/1471-2334-10-18 [doi]
PST - epublish
SO  - BMC Infect Dis. 2010 Jan 26;10:18. doi: 10.1186/1471-2334-10-18.