PMID- 20102776
OWN - NLM
STAT- MEDLINE
DCOM- 20100913
LR  - 20211020
IS  - 1532-8600 (Electronic)
IS  - 0026-0495 (Print)
IS  - 0026-0495 (Linking)
VI  - 59
IP  - 9
DP  - 2010 Sep
TI  - Endothelial function in individuals with coronary artery disease with and without 
      type 2 diabetes mellitus.
PG  - 1365-71
LID - 10.1016/j.metabol.2009.12.023 [doi]
AB  - The goal of this study was to determine if individuals with coronary artery 
      disease (CAD) and type 2 diabetes mellitus (T2DM) had greater endothelial 
      dysfunction (ED) than individuals with only CAD. Flow-mediated dilation (FMD), 
      calculated as percentage increase in brachial artery diameter in response to 
      postischemic blood flow, was measured after an overnight fast in 2 cohorts. The 
      first cohort included 76 participants in the Northern Manhattan Study with CAD; 
      25 also had T2DM. The second cohort was composed of 27 individuals with both T2DM 
      and CAD who were participants in a study of postprandial lipemia. Combined, we 
      analyzed 103 patients with CAD: 52 with T2DM (T2DM+) and 51 without T2DM (T2DM-). 
      The 52 CAD T2DM+ subjects had a mean FMD of 3.9% +/- 3.2%, whereas the 51 CAD 
      T2DM- subjects had a greater mean FMD of 5.5% +/- 4.0% (P < .03). An 
      investigation of various confounders known to affect FMD identified age and body 
      mass index as the only significant covariates in a multiple regression model. 
      Adjusting for age and body mass index, we found that FMD remained lower in T2DM+ 
      subjects compared with T2DM- subjects (difference, -1.99%; P < .03). In patients 
      with CAD, the concomitant presence of T2DM is independently associated with 
      greater ED, as measured by FMD. This finding may be relevant to the greater early 
      and late morbidity and mortality observed in patients with both CAD and T2DM.
CI  - Copyright 2010 Elsevier Inc. All rights reserved.
FAU - Reyes-Soffer, Gissette
AU  - Reyes-Soffer G
AD  - Department of Medicine, Columbia University Medical Center, New York, NY 10032, 
      USA.
FAU - Holleran, Steve
AU  - Holleran S
FAU - Di Tullio, Marco R
AU  - Di Tullio MR
FAU - Homma, Shunichi
AU  - Homma S
FAU - Boden-Albala, Bernadette
AU  - Boden-Albala B
FAU - Ramakrishnan, Rajasekhar
AU  - Ramakrishnan R
FAU - Elkind, Mitchell S
AU  - Elkind MS
FAU - Sacco, Ralph L
AU  - Sacco RL
FAU - Ginsberg, Henry N
AU  - Ginsberg HN
LA  - eng
GR  - M01 RR000645/RR/NCRR NIH HHS/United States
GR  - T32 HL007343-30/HL/NHLBI NIH HHS/United States
GR  - M01 RR00645-25/RR/NCRR NIH HHS/United States
GR  - P01 HL57217/HL/NHLBI NIH HHS/United States
GR  - T32 HL007343/HL/NHLBI NIH HHS/United States
GR  - T32HL07343/HL/NHLBI NIH HHS/United States
GR  - M01 RR000645-270806/RR/NCRR NIH HHS/United States
GR  - P01 HL057217-05/HL/NHLBI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
DEP - 20100127
PL  - United States
TA  - Metabolism
JT  - Metabolism: clinical and experimental
JID - 0375267
RN  - 0 (Blood Glucose)
RN  - 0 (Lipids)
SB  - IM
MH  - Blood Flow Velocity
MH  - Blood Glucose
MH  - Body Mass Index
MH  - Brachial Artery/*physiopathology
MH  - Cohort Studies
MH  - Coronary Artery Disease/blood/complications/*physiopathology
MH  - Diabetes Mellitus, Type 2/blood/complications/*physiopathology
MH  - Endothelium, Vascular/*physiopathology
MH  - Enzyme-Linked Immunosorbent Assay
MH  - Female
MH  - Humans
MH  - Lipids/blood
MH  - Male
MH  - Regional Blood Flow
MH  - Regression Analysis
PMC - PMC2891205
MID - NIHMS168495
EDAT- 2010/01/28 06:00
MHDA- 2010/09/14 06:00
PMCR- 2011/09/01
CRDT- 2010/01/28 06:00
PHST- 2009/04/08 00:00 [received]
PHST- 2009/12/18 00:00 [revised]
PHST- 2009/12/21 00:00 [accepted]
PHST- 2010/01/28 06:00 [entrez]
PHST- 2010/01/28 06:00 [pubmed]
PHST- 2010/09/14 06:00 [medline]
PHST- 2011/09/01 00:00 [pmc-release]
AID - S0026-0495(09)00535-6 [pii]
AID - 10.1016/j.metabol.2009.12.023 [doi]
PST - ppublish
SO  - Metabolism. 2010 Sep;59(9):1365-71. doi: 10.1016/j.metabol.2009.12.023. Epub 2010 
      Jan 27.