PMID- 20104459
OWN - NLM
STAT- MEDLINE
DCOM- 20100402
LR  - 20151119
IS  - 1898-018X (Electronic)
IS  - 1898-018X (Linking)
VI  - 17
IP  - 1
DP  - 2010
TI  - Evaluation of autonomic imbalance in patients with heart failure: a preliminary 
      study of pupillomotor function.
PG  - 65-72
AB  - BACKGROUND: Purpose of this study was to examine pupil size changes and mobility 
      in normal subjects and in heart failure (HF) patients. METHODS: Sixteen stable 
      patients with New York Heart Association (NYHA) class II or III heart failure and 
      sixteen control subjects were studied. Pupillary reaction to light was recorded 
      and nine parameters from this data were measured, reported and then compared in 
      both groups of subjects. RESULTS: Patients with HF had abnormal pupillary 
      function compared with normal subjects. Pupillary light reflex variables differed 
      significantly between two groups (p < 0.05) except baseline radius (R1), minimum 
      radius (R2) and time for maximum constriction (T3). A significant decrease in 
      maximum constriction velocity (VCmax; p < 0.001) and maximum constriction 
      acceleration (ACmax; p < 0.001) was observed in HF subjects. Furthermore, 
      significantly higher values in percentage recovery-redilatation (%R; p < 0.001), 
      percentage R2/R1 (%R2/R1; p < 0.05), latency (T1; p < 0.05) and time for maximum 
      velocity (T2; p < 0.05) were found in the same group. CONCLUSIONS: Of the 
      parameters studied, R1 and %R are governed mainly by the action of the 
      sympathetic nervous system, through norepinephrine. The rest are governed mainly 
      by parasympathetic nervous system, through acetylcholine. The results of our 
      study demonstrate generalized adrenergic activation and parasympathetic 
      withdrawal, which are present in HF.
FAU - Keivanidou, Anastasia
AU  - Keivanidou A
AD  - Laboratory of Clinical Neurophysiology, AHEPA Hospital, Medical Faculty, 
      Aristotle University of Thessaloniki, Greece. keivanidou@yahoo.com
FAU - Fotiou, Dimitris
AU  - Fotiou D
FAU - Arnaoutoglou, Christos
AU  - Arnaoutoglou C
FAU - Arnaoutoglou, Marianthi
AU  - Arnaoutoglou M
FAU - Fotiou, Fotios
AU  - Fotiou F
FAU - Karlovasitou, Anna
AU  - Karlovasitou A
LA  - eng
PT  - Journal Article
PL  - Poland
TA  - Cardiol J
JT  - Cardiology journal
JID - 101392712
RN  - X4W3ENH1CV (Norepinephrine)
SB  - IM
CIN - Cardiol J. 2010;17(6):652; author reply 653-4. PMID: 21154276
MH  - Aged
MH  - Autonomic Nervous System/*physiopathology
MH  - Heart Failure/*physiopathology
MH  - Humans
MH  - Infrared Rays
MH  - Middle Aged
MH  - Norepinephrine/blood
MH  - Parasympathetic Nervous System/physiopathology
MH  - *Reflex, Pupillary
MH  - Sympathetic Nervous System/physiopathology
MH  - Time Factors
EDAT- 2010/01/28 06:00
MHDA- 2010/04/03 06:00
CRDT- 2010/01/28 06:00
PHST- 2010/01/28 06:00 [entrez]
PHST- 2010/01/28 06:00 [pubmed]
PHST- 2010/04/03 06:00 [medline]
PST - ppublish
SO  - Cardiol J. 2010;17(1):65-72.