PMID- 20104647
OWN - NLM
STAT- MEDLINE
DCOM- 20100416
LR  - 20221207
IS  - 1862-1783 (Electronic)
IS  - 1673-1581 (Print)
IS  - 1673-1581 (Linking)
VI  - 11
IP  - 2
DP  - 2010 Feb
TI  - Distributions of HLA-A and -B alleles and haplotypes in the Yi ethnic minority of 
      Yunnan, China: relationship to other populations.
PG  - 127-35
LID - 10.1631/jzus.B0900232 [doi]
AB  - OBJECTIVE: To investigate the distributions of human leukocyte antigen (HLA)-A 
      and -B alleles and HLA-A-B haplotypes in the Yi ethnic minority of the Yunnan 
      Province, situated in southwestern China. METHODS: DNA typing for HLA-A and -B 
      loci was performed using the polymerase chain reaction-sequence-based typing 
      (PCR-SBT) method on 114 randomly selected healthy individuals of the Yi 
      population. The allelic frequencies of HLA-A and -B loci were calculated by 
      direct counting and HLA-A-B haplotypes were estimated using the expectation 
      maximization algorithm. RESULTS: A total of 17 HLA-A and 38 HLA-B alleles were 
      found in the Yi population. The most frequent alleles were A*2402 (32.46%), 
      A*1101 (26.32%), and A*0203 (10.09%) at the HLA-A locus and B*4601 (12.28%), 
      B*1525 (10.09%), B*4001 (8.77%), and B*3802 (7.89%) at the HLA-B locus. The 
      predominant HLA-A-B haplotypes were A*2402-B*1525 (7.86%) and A*0203-B*3802 
      (5.64%), followed by A*1101-B*4001 (4.69%). Phylogenetic analysis indicates that 
      the Yi population in the Honghe, Yunnan Province of China basically belongs to 
      groups of southeastern Asian origin, but shares some characteristics with 
      northeastern Asian groups. CONCLUSION: The present study may add to the 
      understanding of HLA polymorphism in the Yi ethnic group that was poorly defined 
      previously, and provide useful information for bone marrow transplantation, 
      anthropological research, and forensic sciences as well as for 
      disease-association studies.
FAU - Zhu, Bo-feng
AU  - Zhu BF
AD  - Department of Forensic Medicine, School of Medicine, Xi'an Jiaotong University, 
      Xi'an 710061, China.
FAU - Yang, Guang
AU  - Yang G
FAU - Shen, Chun-mei
AU  - Shen CM
FAU - Qin, Hai-xia
AU  - Qin HX
FAU - Liu, Shun-zhi
AU  - Liu SZ
FAU - Deng, Ya-jun
AU  - Deng YJ
FAU - Fan, Shuan-liang
AU  - Fan SL
FAU - Deng, Li-bin
AU  - Deng LB
FAU - Chen, Feng
AU  - Chen F
FAU - Zhang, Ping
AU  - Zhang P
FAU - Fang, Jie
AU  - Fang J
FAU - Chen, Li-ping
AU  - Chen LP
FAU - Wang, Hong-dan
AU  - Wang HD
FAU - Wang, Zhen-yuan
AU  - Wang ZY
FAU - Lucas, Rudolf
AU  - Lucas R
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - China
TA  - J Zhejiang Univ Sci B
JT  - Journal of Zhejiang University. Science. B
JID - 101236535
RN  - 0 (HLA-A Antigens)
RN  - 0 (HLA-B Antigens)
SB  - IM
MH  - Algorithms
MH  - Alleles
MH  - Asian People/*genetics
MH  - China
MH  - Ethnicity/*genetics
MH  - Gene Frequency
MH  - HLA-A Antigens/*genetics
MH  - HLA-B Antigens/*genetics
MH  - Haplotypes
MH  - Humans
MH  - Phylogeny
PMC - PMC2816316
EDAT- 2010/01/28 06:00
MHDA- 2010/04/17 06:00
PMCR- 2010/02/01
CRDT- 2010/01/28 06:00
PHST- 2010/01/28 06:00 [entrez]
PHST- 2010/01/28 06:00 [pubmed]
PHST- 2010/04/17 06:00 [medline]
PHST- 2010/02/01 00:00 [pmc-release]
AID - 10.1631/jzus.B0900232 [doi]
PST - ppublish
SO  - J Zhejiang Univ Sci B. 2010 Feb;11(2):127-35. doi: 10.1631/jzus.B0900232.