PMID- 20105104
OWN - NLM
STAT- MEDLINE
DCOM- 20100601
LR  - 20221207
IS  - 1538-2443 (Electronic)
IS  - 1355-0284 (Print)
IS  - 1355-0284 (Linking)
VI  - 16
IP  - 1
DP  - 2010 Feb
TI  - Role of human leukocyte antigen class I alleles in progressive multifocal 
      leukoencephalopathy.
PG  - 41-7
LID - 10.3109/13550280903552438 [doi]
AB  - Because human leukocyte antigen (HLA) associations with various infectious 
      diseases have recently been reported, we examined the role of HLA class I alleles 
      in the development of progressive multifocal leukoencephalopathy (PML) or its 
      outcome in 152 patients, including 123 Caucasians and 29 African Americans. 
      Compared to a human immunodeficiency virus positive (HIV+) control population, we 
      observed decreased frequency of HLA-A3 (P = 0.03) in the Caucasian PML group, 
      whereas B18 (P = 0.02), was more frequent. No such difference was found among 
      African American PML patients. We then sought to characterize differences in HLA 
      between PML progressors, whose survival doesn't exceed 1 year, and survivors. 
      Caucasian survivors were less likely to harbor A68 (P = 0.01), whereas African 
      American survivors less frequently displayed Cw4 (P = .01). However, none of 
      these differences reached statistical significance after Bonferroni correction 
      for multiple testing. Further investigations are needed to assess the role of 
      genetics in the incidence of PML or its outcome. Physicians may exercise caution 
      in the use of immunomodulatory medications in patients whose genetic background 
      is associated with an increased risk of PML.
FAU - Gheuens, Sarah
AU  - Gheuens S
AD  - Division of Viral Pathogenesis, Beth Israel Deaconess Medical Center, E/CLS-1005, 
      330 Brookline Avenue, Boston, MA 02215, USA.
FAU - Fellay, Jacques
AU  - Fellay J
FAU - Goldstein, David B
AU  - Goldstein DB
FAU - Koralnik, Igor J
AU  - Koralnik IJ
LA  - eng
GR  - U01-AI-35043/AI/NIAID NIH HHS/United States
GR  - R01 CA047006/CA/NCI NIH HHS/United States
GR  - U01-AI-35041/AI/NIAID NIH HHS/United States
GR  - T32 CA09031-32/CA/NCI NIH HHS/United States
GR  - R01 NS041198-09/NS/NINDS NIH HHS/United States
GR  - R01 NS047029-06/NS/NINDS NIH HHS/United States
GR  - U01 AI035043/AI/NIAID NIH HHS/United States
GR  - U01 AI035040/AI/NIAID NIH HHS/United States
GR  - U01 AI035039/AI/NIAID NIH HHS/United States
GR  - T32 CA009031-32/CA/NCI NIH HHS/United States
GR  - T32 AI007387/AI/NIAID NIH HHS/United States
GR  - U01 AI035042/AI/NIAID NIH HHS/United States
GR  - K24 NS 060950/NS/NINDS NIH HHS/United States
GR  - U01 AI067854/AI/NIAID NIH HHS/United States
GR  - U19 AI067854-02/AI/NIAID NIH HHS/United States
GR  - U01-AI-35042/AI/NIAID NIH HHS/United States
GR  - K24 NS060950-02/NS/NINDS NIH HHS/United States
GR  - 5-M01-RR-00052/RR/NCRR NIH HHS/United States
GR  - U01 AI035041/AI/NIAID NIH HHS/United States
GR  - AI067854/AI/NIAID NIH HHS/United States
GR  - U19 AI067854/AI/NIAID NIH HHS/United States
GR  - M01 RR000052/RR/NCRR NIH HHS/United States
GR  - NS 047029/NS/NINDS NIH HHS/United States
GR  - U01-AI-35040/AI/NIAID NIH HHS/United States
GR  - R01 NS 041198/NS/NINDS NIH HHS/United States
GR  - R01 NS041198/NS/NINDS NIH HHS/United States
GR  - T32 CA009031/CA/NCI NIH HHS/United States
GR  - U01-AI-35039/AI/NIAID NIH HHS/United States
GR  - R01 NS047029/NS/NINDS NIH HHS/United States
GR  - K24 NS060950/NS/NINDS NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PL  - United States
TA  - J Neurovirol
JT  - Journal of neurovirology
JID - 9508123
RN  - 0 (HLA-A Antigens)
RN  - 0 (HLA-A*68 antigen)
RN  - 0 (HLA-A3 Antigen)
RN  - 0 (HLA-B Antigens)
RN  - 0 (HLA-B18 Antigen)
RN  - 0 (HLA-C Antigens)
RN  - 0 (HLA-C*04 antigen)
RN  - 0 (Histocompatibility Antigens Class I)
SB  - IM
MH  - AIDS-Related Opportunistic Infections/*genetics/*immunology/pathology
MH  - Black or African American
MH  - Disease Progression
MH  - Gene Frequency
MH  - Genetic Predisposition to Disease
MH  - HIV
MH  - HLA-A Antigens/classification/genetics
MH  - HLA-A3 Antigen/classification/genetics
MH  - HLA-B Antigens/classification/genetics
MH  - HLA-B18 Antigen
MH  - HLA-C Antigens/classification/genetics
MH  - Histocompatibility Antigens Class I/*genetics/*immunology
MH  - Humans
MH  - JC Virus
MH  - Leukoencephalopathy, Progressive Multifocal/*genetics/*immunology/pathology
MH  - Serotyping
MH  - White People
PMC - PMC2854537
MID - NIHMS185094
EDAT- 2010/01/29 06:00
MHDA- 2010/06/02 06:00
PMCR- 2011/02/01
CRDT- 2010/01/29 06:00
PHST- 2010/01/29 06:00 [entrez]
PHST- 2010/01/29 06:00 [pubmed]
PHST- 2010/06/02 06:00 [medline]
PHST- 2011/02/01 00:00 [pmc-release]
AID - 10.3109/13550280903552438 [doi]
PST - ppublish
SO  - J Neurovirol. 2010 Feb;16(1):41-7. doi: 10.3109/13550280903552438.