PMID- 20105138
OWN - NLM
STAT- MEDLINE
DCOM- 20101116
LR  - 20111117
IS  - 1600-0404 (Electronic)
IS  - 0001-6314 (Linking)
VI  - 122
IP  - 1
DP  - 2010 Jul
TI  - Immunoglobulin IgG Fc-receptor polymorphisms and HLA class II molecules in 
      Guillain-Barre syndrome.
PG  - 21-6
LID - 10.1111/j.1600-0404.2009.01229.x [doi]
AB  - OBJECTIVE: To analyze host genetic factors immunoglobulin G Fc receptors 
      (FcgammaRs) and human leukocyte antigen (HLA) class II in GBS patients. METHODS: 
      FcgammaRIIA, IIIA and IIIB polymorphisms were studied in 80 each GBS patients and 
      healthy controls by allele specific PCR. HLA class II DRbeta1 and DQbeta1 typing 
      was performed at the two-digit level by PCR in randomly selected 54 GBS patients 
      and 202 controls. RESULTS: FcgammaRIIA-H/H (56% vs 9%; P < 0.0001) and 
      FcgammaRIIIA-V/V (40% vs 13%; P < 0.0001) genotypes, H131 allele frequencies 
      (0.73 vs 0.26, P < 0.0001) and HLA DQbeta1*060x (OR, 1.96; 95% CI, 1.26-3.04; P < 
      0.01) were significantly increased in GBS than controls. DRbeta1*0701 alone (OR, 
      10; 95% CI, 45.90-2.25; P < 0.001) and together with FcgammaRIIA-H/H (OR, 11.03; 
      95% CI, 2.63-46.20; P < 0.001) was significantly associated with GBS patients 
      having microbiological evidence of recent infection. CONCLUSIONS: The study 
      indicates that homozygous FcgammaRIIA and FcgammaRIIIA genotypes and FcgammaRIIA 
      H131 allele are associated with GBS. HLA class II molecule DRbeta1*0701 is 
      identified as novel genetic risk factor for development of GBS in patients with 
      preceding infection.
FAU - Sinha, S
AU  - Sinha S
AD  - Department of Microbiology, Sanjay Gandhi Postgraduate Institute of Medical 
      Sciences, Lucknow, India.
FAU - Prasad, K N
AU  - Prasad KN
FAU - Jain, D
AU  - Jain D
FAU - Nyati, K K
AU  - Nyati KK
FAU - Pradhan, S
AU  - Pradhan S
FAU - Agrawal, S
AU  - Agrawal S
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20100125
PL  - Denmark
TA  - Acta Neurol Scand
JT  - Acta neurologica Scandinavica
JID - 0370336
RN  - 0 (FCGR3A protein, human)
RN  - 0 (FCGR3B protein, human)
RN  - 0 (Fc gamma receptor IIA)
RN  - 0 (GPI-Linked Proteins)
RN  - 0 (HLA-DQ Antigens)
RN  - 0 (HLA-DQ beta-Chains)
RN  - 0 (HLA-DQB1 antigen)
RN  - 0 (HLA-DR Antigens)
RN  - 0 (HLA-DRB1 Chains)
RN  - 0 (Receptors, IgG)
SB  - IM
MH  - Adult
MH  - Alleles
MH  - Female
MH  - GPI-Linked Proteins
MH  - Genetic Predisposition to Disease
MH  - Guillain-Barre Syndrome/genetics/*immunology
MH  - HLA-DQ Antigens/*genetics/immunology
MH  - HLA-DQ beta-Chains
MH  - HLA-DR Antigens/*genetics/immunology
MH  - HLA-DRB1 Chains
MH  - Humans
MH  - Male
MH  - Polymerase Chain Reaction
MH  - Polymorphism, Genetic
MH  - Receptors, IgG/*genetics/*immunology
EDAT- 2010/01/29 06:00
MHDA- 2010/11/17 06:00
CRDT- 2010/01/29 06:00
PHST- 2010/01/29 06:00 [entrez]
PHST- 2010/01/29 06:00 [pubmed]
PHST- 2010/11/17 06:00 [medline]
AID - ANE1229 [pii]
AID - 10.1111/j.1600-0404.2009.01229.x [doi]
PST - ppublish
SO  - Acta Neurol Scand. 2010 Jul;122(1):21-6. doi: 10.1111/j.1600-0404.2009.01229.x. 
      Epub 2010 Jan 25.