PMID- 20105452
OWN - NLM
STAT- MEDLINE
DCOM- 20100422
LR  - 20100301
IS  - 1872-7972 (Electronic)
IS  - 0304-3940 (Linking)
VI  - 472
IP  - 1
DP  - 2010 Mar 12
TI  - Lack of genetic association of neutral endopeptidase (NEP) with complex regional 
      pain syndrome (CRPS).
PG  - 19-23
LID - 10.1016/j.neulet.2010.01.044 [doi]
AB  - Complex regional pain syndrome (CRPS) is a condition that is characterized by 
      severe pain and exaggerated neurogenic inflammation, which may develop after 
      injury or surgery. Neurogenic inflammation is mediated by neuropeptides, such as 
      calcitonin gene-related peptide (CGRP) and substance P (SP) that are released 
      from nociceptors. Genetic factors may play a role in CRPS as was suggested by the 
      occurrence of familial cases and several genetic association studies 
      investigating mainly the human leukocyte antigen (HLA) system. Here we 
      investigated the role of neutral endopeptidase (NEP), a key enzyme in 
      neuropeptide catabolism. NEP dysfunction resulting in reduced inactivation of 
      neuropeptides may be a possible pathomechanism in CRPS. To this end, we tested a 
      GT-repeat polymorphism in the NEP promoter region as well as 18 tag-SNPs in six 
      linkage disequilibrium (LD) blocks in the NEP gene region in 320 CRPS patients 
      and 376 controls. No significant genetic association was observed. Thus, we 
      conclude that the NEP gene does not seem to be a major risk factor for CRPS.
CI  - Copyright 2010 Elsevier Ireland Ltd. All rights reserved.
FAU - Huehne, Kathrin
AU  - Huehne K
AD  - Institute of Human Genetics, University Hospital Erlangen-Nuremberg, 
      Schwabachanlage 10, 91054 Erlangen, Germany. Kathrin.Huehne@uk-erlangen.de
FAU - Schaal, Ute
AU  - Schaal U
FAU - Leis, Stefan
AU  - Leis S
FAU - Uebe, Steffen
AU  - Uebe S
FAU - Gosso, M Florencia
AU  - Gosso MF
FAU - van den Maagdenberg, Arn M J M
AU  - van den Maagdenberg AM
FAU - Maihofner, Christian
AU  - Maihofner C
FAU - Birklein, Frank
AU  - Birklein F
FAU - Rautenstrauss, Bernd
AU  - Rautenstrauss B
FAU - Winterpacht, Andreas
AU  - Winterpacht A
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20100125
PL  - Ireland
TA  - Neurosci Lett
JT  - Neuroscience letters
JID - 7600130
RN  - EC 3.4.24.11 (Neprilysin)
SB  - IM
MH  - 5' Flanking Region
MH  - Adult
MH  - Case-Control Studies
MH  - Complex Regional Pain Syndromes/*genetics
MH  - Dinucleotide Repeats
MH  - Female
MH  - Genetic Association Studies
MH  - Genetic Predisposition to Disease
MH  - Humans
MH  - Linkage Disequilibrium
MH  - Male
MH  - Middle Aged
MH  - Neprilysin/*genetics
MH  - Polymorphism, Genetic
MH  - Promoter Regions, Genetic
EDAT- 2010/01/29 06:00
MHDA- 2010/04/23 06:00
CRDT- 2010/01/29 06:00
PHST- 2009/12/07 00:00 [received]
PHST- 2010/01/18 00:00 [revised]
PHST- 2010/01/19 00:00 [accepted]
PHST- 2010/01/29 06:00 [entrez]
PHST- 2010/01/29 06:00 [pubmed]
PHST- 2010/04/23 06:00 [medline]
AID - S0304-3940(10)00082-0 [pii]
AID - 10.1016/j.neulet.2010.01.044 [doi]
PST - ppublish
SO  - Neurosci Lett. 2010 Mar 12;472(1):19-23. doi: 10.1016/j.neulet.2010.01.044. Epub 
      2010 Jan 25.