PMID- 20106477
OWN - NLM
STAT- MEDLINE
DCOM- 20101206
LR  - 20220408
IS  - 1879-1484 (Electronic)
IS  - 0021-9150 (Linking)
VI  - 210
IP  - 2
DP  - 2010 Jun
TI  - Increased levels of resistin in rotating shift workers: a potential mediator of 
      cardiovascular risk associated with circadian misalignment.
PG  - 625-9
LID - 10.1016/j.atherosclerosis.2009.12.032 [doi]
AB  - OBJECTIVE: Shift work schedule has been associated with several health problems, 
      including deleterious effects on the cardiovascular system. The present study 
      aimed to evaluate the circulating levels of four biomarkers of atherosclerosis 
      (soluble CD40 ligand [sCD40L], monocyte chemoattractant protein-1 [MCP-1], 
      resistin, and plasminogen activator inhibitor-1 [PAI-1]) in a population-based 
      sample of young adult men exposed to rotating shift work schedule in comparison 
      with day workers. DESIGN AND PARTICIPANTS: A total of 439 men aged 34.4+/-8.6 
      years were included in a cross-sectional study comparing 255 day workers with 184 
      rotating shift workers. Circulating levels of the biomarkers were measured in 
      duplicate by ELISA using monoclonal specific antibodies. RESULTS: Rotating shift 
      workers had elevated (6440+/-4510 pg/mL) (mean+/-SD) circulating levels of 
      resistin in comparison with day workers (5450+/-3780 pg/mL), and significance 
      remains after adjusting for age and blood leukocyte count (p<0.045, ANCOVA). 
      Shift work schedule explains 1% of the proportion of the total variation in the 
      circulating resistin levels. Multiple regression analysis showed that resistin 
      levels significantly correlate with rotating shift work (p<0.04) and blood 
      leukocyte count (p<0.00003) independently of age, BMI, waist-hip ratio, HOMA, and 
      cardiovascular risk %. Circulating levels of sCD40L, MCP-1, and PAI-1 did not 
      significantly differ between day workers and shift workers. CONCLUSION: Shift 
      work schedule was significantly associated with elevated plasma resistin levels. 
      Resistin, which is probably produced by leukocytes, may play an important role in 
      the pathogenesis of early metabolic syndrome components in young men chronically 
      exposed to circadian misalignment.
CI  - Copyright (c) 2009 Elsevier Ireland Ltd. All rights reserved.
FAU - Burgueno, Adriana
AU  - Burgueno A
AD  - Molecular Genetics and Biology of Complex Diseases Department, Institute of 
      Medical Research A Lanari-IDIM, University of Buenos Aires-National Council of 
      Scientific and Technological Research (CONICET), Ciudad Autonoma de Buenos Aires, 
      Argentina.
FAU - Gemma, Carolina
AU  - Gemma C
FAU - Gianotti, Tomas Fernandez
AU  - Gianotti TF
FAU - Sookoian, Silvia
AU  - Sookoian S
FAU - Pirola, Carlos Jose
AU  - Pirola CJ
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20100104
PL  - Ireland
TA  - Atherosclerosis
JT  - Atherosclerosis
JID - 0242543
RN  - 0 (Antibodies, Monoclonal)
RN  - 0 (CCL2 protein, human)
RN  - 0 (Chemokine CCL2)
RN  - 0 (Plasminogen Activator Inhibitor 1)
RN  - 0 (Resistin)
RN  - 0 (SERPINE1 protein, human)
RN  - 147205-72-9 (CD40 Ligand)
SB  - IM
MH  - Adult
MH  - Antibodies, Monoclonal/metabolism
MH  - Atherosclerosis/blood/diagnosis
MH  - CD40 Ligand/blood
MH  - Cardiovascular Diseases/*blood
MH  - Cardiovascular System
MH  - Chemokine CCL2/blood
MH  - Circadian Rhythm
MH  - Cross-Sectional Studies
MH  - *Gene Expression Regulation
MH  - Humans
MH  - Male
MH  - Plasminogen Activator Inhibitor 1/blood
MH  - Resistin/*blood
MH  - *Work Schedule Tolerance
EDAT- 2010/01/29 06:00
MHDA- 2010/12/14 06:00
CRDT- 2010/01/29 06:00
PHST- 2009/09/08 00:00 [received]
PHST- 2009/12/01 00:00 [revised]
PHST- 2009/12/19 00:00 [accepted]
PHST- 2010/01/29 06:00 [entrez]
PHST- 2010/01/29 06:00 [pubmed]
PHST- 2010/12/14 06:00 [medline]
AID - S0021-9150(09)01083-1 [pii]
AID - 10.1016/j.atherosclerosis.2009.12.032 [doi]
PST - ppublish
SO  - Atherosclerosis. 2010 Jun;210(2):625-9. doi: 
      10.1016/j.atherosclerosis.2009.12.032. Epub 2010 Jan 4.