PMID- 20106959
OWN - NLM
STAT- MEDLINE
DCOM- 20100503
LR  - 20220318
IS  - 1758-535X (Electronic)
IS  - 1079-5006 (Print)
IS  - 1079-5006 (Linking)
VI  - 65
IP  - 5
DP  - 2010 May
TI  - Sex hormone-binding globulin as an independent predictor of incident type 2 
      diabetes mellitus in men.
PG  - 503-9
LID - 10.1093/gerona/glq002 [doi]
AB  - BACKGROUND: Low levels of sex hormone-binding globulin (SHBG) and total 
      testosterone (T) in men have been associated with increased risk of type 2 
      diabetes mellitus (T2DM). As total T and SHBG levels are highly correlated, we 
      determined whether SHBG influences the risk of T2DM through T or whether SHBG is 
      an independent predictor of T2DM. METHODS: Longitudinal analyses were conducted 
      on men participating in the Massachusetts Male Aging Study, a population-based 
      study of men aged 40-70 years. Of 1,709 men enrolled in 1987-1989, 1,156 were 
      evaluated 7-10 years later and 853 after 15-17 years. Analyses were restricted to 
      1,128 men without T2DM at baseline. RESULTS: Ninety new cases of T2DM were 
      identified. After adjustment for age, body mass index, hypertension, smoking, 
      alcohol intake, and physical activity, the hazard ratio (HR) for incident T2DM 
      was 2.0 for each 1 SD decrease in SHBG (95% confidence interval [CI], 1.42-2.82, 
      p < .001) and 1.29 for each 1 SD decrease in total T (95% CI, 1.01-1.66, p = 
      .04). Free T was not associated with T2DM (HR = 1.03, 95% CI, 0.81-1.31, p = 
      .79). The strong association of T2DM risk with SHBG persisted even after 
      additional adjustment for free T (HR = 2.04, 95% CI, 1.44-2.87, p < .0001) or 
      total T (HR = 1.95, 95% CI, 1.34-2.82, p = .0004). CONCLUSIONS: SHBG is an 
      independent predictor of incident T2DM even after adjusting for free T or total 
      T. Free T is not significantly associated with T2DM. SHBG may contribute to the 
      risk of T2DM through nonandrogenic mechanisms, which should be investigated as 
      they may provide novel targets for diabetes prevention.
FAU - Lakshman, Kishore M
AU  - Lakshman KM
AD  - Director of Epidemiology, New England Research Institutes, Inc., Watertown, MA 
      02472, USA.
FAU - Bhasin, Shalender
AU  - Bhasin S
FAU - Araujo, Andre B
AU  - Araujo AB
LA  - eng
GR  - R01DK51345/DK/NIDDK NIH HHS/United States
GR  - 1R01AG22356/AG/NIA NIH HHS/United States
GR  - R01DK44995/DK/NIDDK NIH HHS/United States
GR  - R01AG04673/AG/NIA NIH HHS/United States
GR  - 5P30AG031679/AG/NIA NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
DEP - 20100127
PL  - United States
TA  - J Gerontol A Biol Sci Med Sci
JT  - The journals of gerontology. Series A, Biological sciences and medical sciences
JID - 9502837
RN  - 0 (Sex Hormone-Binding Globulin)
RN  - 3XMK78S47O (Testosterone)
SB  - IM
MH  - Adult
MH  - Age Factors
MH  - Aged
MH  - Aging/blood/physiology
MH  - Body Mass Index
MH  - Diabetes Mellitus, Type 2/*blood/physiopathology
MH  - Humans
MH  - Longitudinal Studies
MH  - Male
MH  - Middle Aged
MH  - Proportional Hazards Models
MH  - Regression Analysis
MH  - Risk Factors
MH  - Sex Hormone-Binding Globulin/*analysis
MH  - Testosterone/blood
PMC - PMC2854882
EDAT- 2010/01/29 06:00
MHDA- 2010/05/04 06:00
PMCR- 2011/05/01
CRDT- 2010/01/29 06:00
PHST- 2010/01/29 06:00 [entrez]
PHST- 2010/01/29 06:00 [pubmed]
PHST- 2010/05/04 06:00 [medline]
PHST- 2011/05/01 00:00 [pmc-release]
AID - glq002 [pii]
AID - 10.1093/gerona/glq002 [doi]
PST - ppublish
SO  - J Gerontol A Biol Sci Med Sci. 2010 May;65(5):503-9. doi: 10.1093/gerona/glq002. 
      Epub 2010 Jan 27.