PMID- 20108169
OWN - NLM
STAT- MEDLINE
DCOM- 20100913
LR  - 20240204
IS  - 0219-1032 (Electronic)
IS  - 1016-8478 (Linking)
VI  - 29
IP  - 3
DP  - 2010 Mar
TI  - Increased fat due to estrogen deficiency induces bone loss by elevating monocyte 
      chemoattractant protein-1 (MCP-1) production.
PG  - 277-82
LID - 10.1007/s10059-010-0027-x [doi]
AB  - Ovariectomy (OVX)-induced estrogen withdrawal resulted in both bone loss and an 
      increase in fat. We observed elevated osteoclast (OC) formation by bone 
      marrow-derived macrophages treated with medium conditioned by fats from OVX mice, 
      but not from sham-operated mice. Fats from OVX mice expressed and secreted higher 
      levels of monocyte chemoattractant protein-1 (MCP-1) than those from 
      sham-operated mice. Increased fat resulting from estrogen deficiency is thus 
      responsible for bone loss due to enhanced OC formation, which is, at least 
      partly, a consequence of elevated MCP-1 production.
FAU - Kim, Youn-Young
AU  - Kim YY
AD  - Department of Biological Sciences (Brain Korea 21 Program) and the 
      Immunomodulation Research Center, University of Ulsan, Ulsan, 680-749, Korea.
FAU - Kim, Song-Hee
AU  - Kim SH
FAU - Oh, Sora
AU  - Oh S
FAU - Sul, Ok-Joo
AU  - Sul OJ
FAU - Lee, Hye-Young
AU  - Lee HY
FAU - Kim, Hyun-Ju
AU  - Kim HJ
FAU - Kim, Shin-Yoon
AU  - Kim SY
FAU - Choi, Hye-Seon
AU  - Choi HS
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20100121
PL  - United States
TA  - Mol Cells
JT  - Molecules and cells
JID - 9610936
RN  - 0 (Ccl2 protein, mouse)
RN  - 0 (Chemokine CCL2)
RN  - 0 (Estrogens)
RN  - 0 (RANK Ligand)
RN  - 0 (Recombinant Proteins)
RN  - 0 (Tnfsf11 protein, mouse)
RN  - 81627-83-0 (Macrophage Colony-Stimulating Factor)
SB  - IM
MH  - Adipose Tissue/*metabolism/pathology
MH  - Animals
MH  - Bone Density
MH  - Bone Diseases, Metabolic/*etiology/pathology/physiopathology
MH  - Bone Resorption/*physiopathology
MH  - Cell Differentiation/physiology
MH  - Cells, Cultured/cytology/drug effects
MH  - Chemokine CCL2/biosynthesis/genetics/*physiology
MH  - Estrogens/*deficiency
MH  - Female
MH  - Femur/chemistry/pathology
MH  - Intra-Abdominal Fat/metabolism/pathology
MH  - Macrophage Colony-Stimulating Factor/physiology
MH  - Macrophages/cytology/drug effects
MH  - Mice
MH  - Mice, Inbred C57BL
MH  - Osteoclasts/*pathology
MH  - Ovariectomy
MH  - RANK Ligand/physiology
MH  - Recombinant Proteins/pharmacology
MH  - Subcutaneous Fat/metabolism/pathology
MH  - Weight Gain
EDAT- 2010/01/29 06:00
MHDA- 2010/09/14 06:00
CRDT- 2010/01/29 06:00
PHST- 2009/09/29 00:00 [received]
PHST- 2009/11/16 00:00 [accepted]
PHST- 2009/11/05 00:00 [revised]
PHST- 2010/01/29 06:00 [entrez]
PHST- 2010/01/29 06:00 [pubmed]
PHST- 2010/09/14 06:00 [medline]
AID - S1016-8478(23)12952-9 [pii]
AID - 10.1007/s10059-010-0027-x [doi]
PST - ppublish
SO  - Mol Cells. 2010 Mar;29(3):277-82. doi: 10.1007/s10059-010-0027-x. Epub 2010 Jan 
      21.