PMID- 20109306
OWN - NLM
STAT- MEDLINE
DCOM- 20100611
LR  - 20220331
IS  - 1945-8932 (Electronic)
IS  - 1945-8932 (Linking)
VI  - 24
IP  - 1
DP  - 2010 Jan-Feb
TI  - Association of the CD14 gene polymorphism C-159T with allergic rhinitis.
PG  - e1-3
LID - 10.2500/ajra.2010.24.3411 [doi]
AB  - BACKGROUND: Altered expression of the cluster differentiation antigen, CD14, may 
      affect the proportion of T-helper type 1 (Th1) to Th2 cells, thereby influencing 
      the immunoglobulin E (IgE) response and associated inflammatory phenotype in 
      allergic conditions. Therefore, the gene encoding CD14 is considered as a 
      positional candidate gene for atopy. Recently, a functional C-159 T polymorphism 
      has been described in the promoter region of the gene and has been associated 
      with increased gene expression and atopic phenotypes in various ethnic 
      populations. We evaluated the relationship between the C-159 T polymorphism in 
      the promoter of the CD14 gene and the total serum IgE level in Chinese adult 
      patients with allergic rhinitis. METHODS: Polymerase chain reaction with 
      restriction fragment length polymorphism (RFLP) analysis was used to determine 
      the C-159 T polymorphism in subjects with allergic rhinitis (n = 92) and 
      nonallergic disease controls (n = 72). Total serum IgE was also measured. 
      RESULTS: In the allergic rhinitis group, the frequency of the TT homozygotes was 
      significantly higher than for the control group (p < 0.05). In both groups, the 
      C-159 T polymorphism is not associated with serum IgE levels. CONCLUSION: TT 
      homozygotes are more common in adult patients with allergic rhinitis among the 
      Chinese population.
FAU - Han, Demin
AU  - Han D
AD  - Key Laboratory of Otolaryngology-Head and Neck Surgery, Capital Medical 
      University, Ministry of Education of China, Beijing Institute of 
      Otorhinolaryngology, Beijing, People's Republic of China.
FAU - She, Wenyu
AU  - She W
FAU - Zhang, Luo
AU  - Zhang L
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Am J Rhinol Allergy
JT  - American journal of rhinology & allergy
JID - 101490775
RN  - 0 (Lipopolysaccharide Receptors)
RN  - 37341-29-0 (Immunoglobulin E)
SB  - IM
MH  - Adult
MH  - Female
MH  - Genetic Association Studies
MH  - Genetic Testing
MH  - Haplotypes
MH  - Humans
MH  - Immunoglobulin E/blood
MH  - Lipopolysaccharide Receptors/*genetics/immunology/*metabolism
MH  - Male
MH  - Middle Aged
MH  - Nasal Obstruction
MH  - *Polymorphism, Genetic
MH  - Promoter Regions, Genetic
MH  - Rhinitis, Allergic, Perennial/blood/*genetics/physiopathology
MH  - Rhinitis, Allergic, Seasonal/blood/*genetics/physiopathology
EDAT- 2010/01/30 06:00
MHDA- 2010/06/12 06:00
CRDT- 2010/01/30 06:00
PHST- 2010/01/30 06:00 [entrez]
PHST- 2010/01/30 06:00 [pubmed]
PHST- 2010/06/12 06:00 [medline]
AID - 10.2500/ajra.2010.24.3411 [doi]
PST - ppublish
SO  - Am J Rhinol Allergy. 2010 Jan-Feb;24(1):e1-3. doi: 10.2500/ajra.2010.24.3411.