PMID- 20109511
OWN - NLM
STAT- MEDLINE
DCOM- 20100624
LR  - 20220318
IS  - 1878-4216 (Electronic)
IS  - 0278-5846 (Linking)
VI  - 34
IP  - 3
DP  - 2010 Apr 16
TI  - Neurocognitive, clinical and functional correlates of subjective quality of life 
      in Asian outpatients with schizophrenia.
PG  - 463-8
LID - 10.1016/j.pnpbp.2010.01.014 [doi]
AB  - Quality of life (QOL) impairment is evident in patients with schizophrenia and is 
      increasingly recognised as an important evaluation criterion of treatment 
      outcome. Hence, this study aimed to identify the neurocognitive, clinical and 
      functional parameters associated with subjective QOL in patients with 
      schizophrenia within an Asian context, and specifically in an outpatient setting. 
      This study was conducted on 83 outpatients with DSM-IV diagnosis of 
      schizophrenia, and 47 age- and gender-matched healthy controls. All participants 
      were administered with the World Health Organisation Quality of Life 
      Assessment-Brief Form (WHOQOL-BREF) and Brief Assessment of Cognition in 
      Schizophrenia (BACS), to measure quality of life and cognitive function 
      respectively. Patients were also assessed for severity of psychopathology, as 
      well as level of psychosocial functioning, using the Positive and Negative 
      Syndrome Scale (PANSS) and Global Assessment of Functioning (GAF) rating scales 
      respectively. Specific psychopathology (greater severity of PANSS negative 
      symptoms, general psychopathology subscale scores), cognitive deficits (working 
      and verbal memories), and lower GAF scores were correlated with poorer QOL in 
      patients. Multivariate analyses revealed that younger age, being single and lower 
      level of psychosocial functioning were associated with poorer QOL but level of 
      psychosocial functioning did not appear to mediate the effects of symptoms and 
      neurocognitive deficits on QOL. Overall, this study highlighted the need for 
      clinicians to pay more attention to these clinical, neurocognitive and functional 
      parameters and their integrative relationships with QOL in order to optimise the 
      treatment outcomes of patients with schizophrenia.
CI  - Copyright 2010 Elsevier Inc. All rights reserved.
FAU - Woon, Puay San
AU  - Woon PS
AD  - Research Division, Institute of Mental Health/Woodbridge Hospital, Singapore.
FAU - Chia, Ming Ying
AU  - Chia MY
FAU - Chan, Wai Yen
AU  - Chan WY
FAU - Sim, Kang
AU  - Sim K
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20100125
PL  - England
TA  - Prog Neuropsychopharmacol Biol Psychiatry
JT  - Progress in neuro-psychopharmacology & biological psychiatry
JID - 8211617
SB  - IM
MH  - Adult
MH  - Asia/ethnology
MH  - Case-Control Studies
MH  - Chi-Square Distribution
MH  - Cognition Disorders/*etiology
MH  - Cross-Sectional Studies
MH  - Female
MH  - Humans
MH  - Male
MH  - Neuropsychological Tests
MH  - Outpatients/psychology
MH  - Psychiatric Status Rating Scales
MH  - *Quality of Life
MH  - Schizophrenia/*complications
MH  - *Schizophrenic Psychology
MH  - Statistics as Topic
EDAT- 2010/01/30 06:00
MHDA- 2010/06/25 06:00
CRDT- 2010/01/30 06:00
PHST- 2009/09/23 00:00 [received]
PHST- 2010/01/20 00:00 [revised]
PHST- 2010/01/20 00:00 [accepted]
PHST- 2010/01/30 06:00 [entrez]
PHST- 2010/01/30 06:00 [pubmed]
PHST- 2010/06/25 06:00 [medline]
AID - S0278-5846(10)00022-9 [pii]
AID - 10.1016/j.pnpbp.2010.01.014 [doi]
PST - ppublish
SO  - Prog Neuropsychopharmacol Biol Psychiatry. 2010 Apr 16;34(3):463-8. doi: 
      10.1016/j.pnpbp.2010.01.014. Epub 2010 Jan 25.