PMID- 20110394
OWN - NLM
STAT- MEDLINE
DCOM- 20110307
LR  - 20161125
IS  - 1399-3003 (Electronic)
IS  - 0903-1936 (Linking)
VI  - 36
IP  - 3
DP  - 2010 Sep
TI  - Ventilatory chemoresponsiveness, narcolepsy-cataplexy and human leukocyte antigen 
      DQB1*0602 status.
PG  - 577-83
LID - 10.1183/09031936.00174609 [doi]
AB  - We hypothesised that hypocretin (orexin) plays a role in the determination of 
      ventilatory chemosensitivity. 130 patients with narcolepsy-cataplexy (mean +/- SD 
      age 20 +/- 10 yrs, 69% male) and 117 controls (22 +/- 6.9 yrs, 62% male) were 
      recruited and tested for human leukocyte antigen (HLA)-DQB1*0602 status, 
      hyperoxia hypercapnic (change in minute ventilation (deltaV'(E))/carbon dioxide 
      tension (deltaP(CO(2))) L.min(-1).mmHg(-1)) and hypoxic (deltaV'(E) /change in arterial 
      oxygen saturation measured by probe oximetry (deltaS(p,O(2))) L.min(-1) per 
      %S(p,O(2))) responsiveness, and by spirometry. Hypocretin deficiency was 
      determined either by measures of cerebrospinal fluid hypocretin-1 (37 patients) 
      or by positive HLA-DQB1*0602 status. All patients and 49% of controls underwent 
      polysomnography and multiple sleep latency testing. Despite similar spirometric 
      values, patients had a higher apnoea/hypopnoea index (AHI) (2.8 +/- 5.4 versus 0.8 
      +/- 1.6 h(-1); p = 0.03) and lower minimal oxygen saturation during sleep (87% +/- 7 
      versus 91 +/- 4%; p = 0.0002), independent of age, sex and body mass index. 
      Patients had depressed hypoxic responsiveness (0.13 +/- 0.09 versus 0.19 +/- 0.13 
      L.min(-1) per %S(p,O(2)); p<0.0001), independent of AHI, but hypercapnic 
      responsiveness did not differ. Examined by HLA status, positive (26 out of 117) 
      controls had lower hypoxic but similar hypercapnic responsiveness than those 
      marker-negative (0.13 +/- 0.08 versus 0.20 +/- 0.14 L.min(-1) per %S(p,O(2)); 
      p<0.0001). Thus, a lower hypoxic responsiveness in the narcolepsy-cataplexy group 
      is a result of DQB1*0602 status rather than the clinical features of disease.
FAU - Han, F
AU  - Han F
AD  - Dept of Pulmonary Medicine, The People's Hospital, Beijing University, Beijing 
      100044, China. hanfang1@hotmail.com
FAU - Mignot, E
AU  - Mignot E
FAU - Wei, Y C
AU  - Wei YC
FAU - Dong, S X
AU  - Dong SX
FAU - Li, J
AU  - Li J
FAU - Lin, L
AU  - Lin L
FAU - An, P
AU  - An P
FAU - Wang, L H
AU  - Wang LH
FAU - Wang, J S
AU  - Wang JS
FAU - He, M Z
AU  - He MZ
FAU - Gao, H Y
AU  - Gao HY
FAU - Li, M
AU  - Li M
FAU - Gao, Z C
AU  - Gao ZC
FAU - Strohl, K P
AU  - Strohl KP
LA  - eng
GR  - NIH 23734/PHS HHS/United States
GR  - Howard Hughes Medical Institute/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, Non-P.H.S.
DEP - 20100128
PL  - England
TA  - Eur Respir J
JT  - The European respiratory journal
JID - 8803460
RN  - 0 (HCRT protein, human)
RN  - 0 (HLA-DQ Antigens)
RN  - 0 (HLA-DQ beta-Chains)
RN  - 0 (HLA-DQB1 antigen)
RN  - 0 (Intracellular Signaling Peptides and Proteins)
RN  - 0 (Membrane Glycoproteins)
RN  - 0 (Neuropeptides)
RN  - 0 (Orexins)
SB  - IM
MH  - Adult
MH  - Body Mass Index
MH  - Cataplexy/genetics/*immunology
MH  - China
MH  - Female
MH  - HLA-DQ Antigens/genetics/*physiology
MH  - HLA-DQ beta-Chains
MH  - Humans
MH  - Hypercapnia
MH  - Hypoxia
MH  - Intracellular Signaling Peptides and Proteins/metabolism
MH  - Male
MH  - Membrane Glycoproteins/genetics/*physiology
MH  - Narcolepsy/genetics/*immunology
MH  - Neuropeptides/metabolism
MH  - Orexins
MH  - *Respiration
MH  - Respiratory Function Tests
MH  - Sleep
MH  - Sleep Wake Disorders/metabolism
EDAT- 2010/01/30 06:00
MHDA- 2011/03/08 06:00
CRDT- 2010/01/30 06:00
PHST- 2010/01/30 06:00 [entrez]
PHST- 2010/01/30 06:00 [pubmed]
PHST- 2011/03/08 06:00 [medline]
AID - 09031936.00174609 [pii]
AID - 10.1183/09031936.00174609 [doi]
PST - ppublish
SO  - Eur Respir J. 2010 Sep;36(3):577-83. doi: 10.1183/09031936.00174609. Epub 2010 
      Jan 28.