PMID- 20110741
OWN - NLM
STAT- MEDLINE
DCOM- 20100916
LR  - 20100602
IS  - 1423-0275 (Electronic)
IS  - 0301-1569 (Linking)
VI  - 72
IP  - 1
DP  - 2010
TI  - Overexpression of SATB1 in laryngeal squamous cell carcinoma.
PG  - 1-5
LID - 10.1159/000264777 [doi]
AB  - OBJECTIVE: To investigate the expression of special AT-rich sequence-binding 
      protein 1 (SATB1), and the relationship between SATB1 and clinicopathological 
      factors of laryngeal squamous cell carcinoma (LSCC). METHODS: Real-time PCR, 
      Western blot and immunohistochemistry were used to analyze 80 samples of LSCC and 
      25 samples of control mucosa. The relationship between SATB1 expression and 
      clinicopathological parameters was evaluated. RESULTS: The SATB1 mRNA expression 
      levels in LSCC were 2.5- to 7.5-fold higher than those in control mucosa tissues 
      (p < 0.001). SATB1 protein expression was detected in approximately 66% (53 out 
      of 80) of the LSCC specimens, whereas it was below the detection limit in all the 
      control mucosa specimens (p < 0.001). The SATB1 mRNA levels in positive cervical 
      lymph nodes, in clinical stages III and IV with poor/moderate cell 
      differentiation, were significantly higher than those in negative cervical lymph 
      nodes in clinical stage II with high cell differentiation (p = 0.022, p = 0.005 
      and p = 0.006, respectively). CONCLUSIONS: SATB1 mRNA and protein levels are 
      elevated in LSCC tissues, and their levels are correlated with clinical stages 
      and differentiation status. The current findings suggest that SATB1 may be a 
      useful marker for the prognosis and assessment of therapeutic effects.
FAU - Zhao, Xu-Dong
AU  - Zhao XD
AD  - Department of Otorhinolaryngology, Shengjing Hospital, China Medical University, 
      Shenyang, PR China.
FAU - Ji, Wen-yue
AU  - Ji WY
FAU - Zhang, Wei
AU  - Zhang W
FAU - He, Li-Xia
AU  - He LX
FAU - Yang, Jing
AU  - Yang J
FAU - Liang, Hong-Jun
AU  - Liang HJ
FAU - Wang, Li-Li
AU  - Wang LL
LA  - eng
PT  - Journal Article
DEP - 20100122
PL  - Switzerland
TA  - ORL J Otorhinolaryngol Relat Spec
JT  - ORL; journal for oto-rhino-laryngology and its related specialties
JID - 0334721
RN  - 0 (Matrix Attachment Region Binding Proteins)
RN  - 0 (SATB1 protein, human)
SB  - IM
MH  - Blotting, Western
MH  - Carcinoma, Squamous Cell/*metabolism/pathology/surgery
MH  - Chi-Square Distribution
MH  - Humans
MH  - Immunohistochemistry
MH  - Laryngeal Neoplasms/*metabolism/pathology/surgery
MH  - Lymphatic Metastasis
MH  - Matrix Attachment Region Binding Proteins/*metabolism
MH  - Reverse Transcriptase Polymerase Chain Reaction
EDAT- 2010/01/30 06:00
MHDA- 2010/09/18 06:00
CRDT- 2010/01/30 06:00
PHST- 2009/10/05 00:00 [received]
PHST- 2009/11/30 00:00 [accepted]
PHST- 2010/01/30 06:00 [entrez]
PHST- 2010/01/30 06:00 [pubmed]
PHST- 2010/09/18 06:00 [medline]
AID - 000264777 [pii]
AID - 10.1159/000264777 [doi]
PST - ppublish
SO  - ORL J Otorhinolaryngol Relat Spec. 2010;72(1):1-5. doi: 10.1159/000264777. Epub 
      2010 Jan 22.