PMID- 20110857
OWN - NLM
STAT- MEDLINE
DCOM- 20100406
LR  - 20100310
IS  - 1534-6080 (Electronic)
IS  - 0041-1337 (Linking)
VI  - 89
IP  - 5
DP  - 2010 Mar 15
TI  - Impact of HLA mismatching on incidence of posttransplant non-hodgkin lymphoma 
      after kidney transplantation.
PG  - 567-72
LID - 10.1097/TP.0b013e3181c69855 [doi]
AB  - BACKGROUND: Posttransplant non-Hodgkin lymphoma is a rare complication but 
      associated with high mortality. The extent to which human leukocyte antigen (HLA) 
      mismatching influences the rate of posttransplant lymphoma has not been 
      clarified. METHODS: Data on lymphomas occurring in the first 3 years 
      posttransplant were analyzed among first kidney transplants from deceased donors 
      performed between 1985 and 2007 and reported to the Collaborative Transplant 
      Study. RESULTS: Of 152,728 patients included, 593 non-Hodgkin lymphomas were 
      diagnosed. Cox multivariate regression analysis showed that HLA-A mismatches had 
      no influence on the rate of lymphoma. One and two HLA-DR mismatches were 
      associated with a hazard ratio (HR) of 1.21 (95% confidence interval 1.00-1.45, 
      P=0.047) and 1.56 (95% confidence interval 1.21-1.99, P<0.001), respectively. For 
      lymphoma of the kidney and central nervous system, HRs for two HLA-DR mismatches 
      were 2.29 (P=0.007) and 2.17 (P=0.029), respectively. Two HLA-B mismatches were 
      also significantly associated with lymphoma in the kidney (HR 2.82, P=0.009). 
      CONCLUSION: Mismatches at the HLA-DR locus are a significant risk factor for 
      posttransplant non-Hodgkin lymphoma, particularly in the kidney and central 
      nervous system, whereas two HLA-B mismatches increase the risk for the 
      development of lymphoma of the kidney.
FAU - Opelz, Gerhard
AU  - Opelz G
AD  - Department of Transplantation Immunology, University of Heidelberg, Im 
      Neuenheimer Feld 305, D-61920 Heidelberg, Germany. 
      gerhard.opelz@med.uni-heidelberg.de
FAU - Dohler, Bernd
AU  - Dohler B
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Transplantation
JT  - Transplantation
JID - 0132144
RN  - 0 (HLA Antigens)
RN  - 0 (HLA-DR Antigens)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Demography
MH  - Female
MH  - HLA Antigens/*immunology
MH  - HLA-DR Antigens/immunology
MH  - Histocompatibility Testing/methods
MH  - Humans
MH  - Incidence
MH  - Kidney Transplantation/adverse effects/*immunology/pathology
MH  - Lymphoma, Non-Hodgkin/*epidemiology
MH  - Male
MH  - Middle Aged
MH  - Postoperative Complications/*epidemiology/pathology
MH  - Young Adult
EDAT- 2010/01/30 06:00
MHDA- 2010/04/07 06:00
CRDT- 2010/01/30 06:00
PHST- 2010/01/30 06:00 [entrez]
PHST- 2010/01/30 06:00 [pubmed]
PHST- 2010/04/07 06:00 [medline]
AID - 10.1097/TP.0b013e3181c69855 [doi]
PST - ppublish
SO  - Transplantation. 2010 Mar 15;89(5):567-72. doi: 10.1097/TP.0b013e3181c69855.