PMID- 20111061
OWN - NLM
STAT- MEDLINE
DCOM- 20110713
LR  - 20151119
IS  - 1476-5454 (Electronic)
IS  - 0950-222X (Linking)
VI  - 24
IP  - 7
DP  - 2010 Jul
TI  - Vitreous levels of interleukine-8 and monocyte chemoattractant protein-1 in 
      macular oedema with branch retinal vein occlusion.
PG  - 1284-90
LID - 10.1038/eye.2009.340 [doi]
AB  - PURPOSE: To investigate whether interleukine-8 (IL-8) and monocyte 
      chemoattractant protein-1 (MCP-1) are related with macular oedema in patients 
      with branch retinal vein occlusions (BRVOs). DESIGN: Retrospective case-control 
      study. PARTICIPANTS: Nineteen patients who had macular oedema due to BRVO and 
      nine patients with non-ischaemic ocular diseases (control group). METHODS: 
      Macular oedema was examined by optical coherence tomography. Both venous blood 
      and vitreous samples were obtained at the time of vitreoretinal surgery. IL-8 and 
      MCP-1 levels in vitreous fluid and plasma were determined with enzyme-linked 
      immunosorbent assay kits. Variables were compared with the Mann-Whitney U-test, 
      Wilcoxon's signed-ranked test, and the chi2-test, when appropriate. To examine 
      correlations, Spearman's rank-order correlation coefficients were calculated. 
      Statistical significance was set at P<0.05. RESULTS: The vitreous fluid levels of 
      IL-8 (median: 63.5 pg/ml) and MCP-1 (median: 1522.4 pg/ml) were significantly 
      higher in the patients with BRVO than in the control group (median: 5.1 and 746.5 
      pg/ml respectively; P<0.001 and <0.001 respectively). Vitreous IL-8 and MCP-1 
      were significantly correlated in patients with BRVO (P=0.009). CONCLUSIONS: Both 
      IL-8 and MCP-1 were elevated in the vitreous fluid of patients with BRVO and 
      macular oedema. Both chemokines may contribute to the pathogenesis of macular 
      oedema in patients with BRVO.
FAU - Fonollosa, A
AU  - Fonollosa A
AD  - Department of Ophthalmology, Hospital Valle Hebron de Barcelona, Barcelona, 
      Spain. 36427afc@comb.es
FAU - Garcia-Arumi, J
AU  - Garcia-Arumi J
FAU - Santos, E
AU  - Santos E
FAU - Macia, C
AU  - Macia C
FAU - Fernandez, P
AU  - Fernandez P
FAU - Segura, R M
AU  - Segura RM
FAU - Zapata, M A
AU  - Zapata MA
FAU - Rodriguez-Infante, R
AU  - Rodriguez-Infante R
FAU - Boixadera, A
AU  - Boixadera A
FAU - Martinez-Castillo, V
AU  - Martinez-Castillo V
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20100129
PL  - England
TA  - Eye (Lond)
JT  - Eye (London, England)
JID - 8703986
RN  - 0 (Biomarkers)
RN  - 0 (Chemokine CXCL2)
RN  - 0 (Interleukin-8)
SB  - IM
MH  - Aged
MH  - Biomarkers/metabolism
MH  - Case-Control Studies
MH  - Chemokine CXCL2/blood/*metabolism
MH  - Enzyme-Linked Immunosorbent Assay
MH  - Female
MH  - Humans
MH  - Interleukin-8/blood/*metabolism
MH  - Macular Edema/etiology/*metabolism
MH  - Male
MH  - Middle Aged
MH  - Retinal Vein Occlusion/complications/*metabolism
MH  - Retrospective Studies
MH  - Tomography, Optical Coherence
MH  - Vitreous Body/*metabolism
EDAT- 2010/01/30 06:00
MHDA- 2011/07/14 06:00
CRDT- 2010/01/30 06:00
PHST- 2010/01/30 06:00 [entrez]
PHST- 2010/01/30 06:00 [pubmed]
PHST- 2011/07/14 06:00 [medline]
AID - eye2009340 [pii]
AID - 10.1038/eye.2009.340 [doi]
PST - ppublish
SO  - Eye (Lond). 2010 Jul;24(7):1284-90. doi: 10.1038/eye.2009.340. Epub 2010 Jan 29.