PMID- 20111591
OWN - NLM
STAT- MEDLINE
DCOM- 20100520
LR  - 20211020
IS  - 1932-6203 (Electronic)
IS  - 1932-6203 (Linking)
VI  - 5
IP  - 1
DP  - 2010 Jan 11
TI  - Plasticity in the rat prefrontal cortex: linking gene expression and an operant 
      learning with a computational theory.
PG  - e8656
LID - 10.1371/journal.pone.0008656 [doi]
LID - e8656
AB  - The plasticity in the medial Prefrontal Cortex (mPFC) of rodents or lateral 
      prefrontal cortex in non human primates (lPFC), plays a key role neural circuits 
      involved in learning and memory. Several genes, like brain-derived neurotrophic 
      factor (BDNF), cAMP response element binding (CREB), Synapsin I, 
      Calcium/calmodulin-dependent protein kinase II (CamKII), activity-regulated 
      cytoskeleton-associated protein (Arc), c-jun and c-fos have been related to 
      plasticity processes. We analysed differential expression of related plasticity 
      genes and immediate early genes in the mPFC of rats during learning an operant 
      conditioning task. Incompletely and completely trained animals were studied 
      because of the distinct events predicted by our computational model at different 
      learning stages. During learning an operant conditioning task, we measured 
      changes in the mRNA levels by Real-Time RT-PCR during learning; expression of 
      these markers associated to plasticity was incremented while learning and such 
      increments began to decline when the task was learned. The plasticity changes in 
      the lPFC during learning predicted by the model matched up with those of the 
      representative gene BDNF. Herein, we showed for the first time that plasticity in 
      the mPFC in rats during learning of an operant conditioning is higher while 
      learning than when the task is learned, using an integrative approach of a 
      computational model and gene expression.
FAU - Rapanelli, Maximiliano
AU  - Rapanelli M
AD  - Instituto de Biologia y Medicina Experimental (CONICET), Laboratorio de Biologia 
      del Comportamiento, Ciudad de Buenos Aires, Buenos Aires, Argentina. 
      rapanelli@dna.uba.ar
FAU - Lew, Sergio Eduardo
AU  - Lew SE
FAU - Frick, Luciana Romina
AU  - Frick LR
FAU - Zanutto, Bonifacio Silvano
AU  - Zanutto BS
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20100111
PL  - United States
TA  - PLoS One
JT  - PloS one
JID - 101285081
RN  - 0 (DNA Primers)
RN  - 0 (RNA, Messenger)
SB  - IM
MH  - Animals
MH  - Base Sequence
MH  - Behavior, Animal
MH  - *Conditioning, Operant
MH  - DNA Primers
MH  - *Gene Expression Regulation
MH  - *Learning
MH  - Male
MH  - *Neuronal Plasticity
MH  - Prefrontal Cortex/*physiology
MH  - RNA, Messenger/genetics
MH  - Rats
MH  - Rats, Long-Evans
MH  - Reverse Transcriptase Polymerase Chain Reaction
PMC - PMC2810321
COIS- Competing Interests: The authors have declared that no competing interests exist.
EDAT- 2010/01/30 06:00
MHDA- 2010/05/21 06:00
PMCR- 2010/01/11
CRDT- 2010/01/30 06:00
PHST- 2009/09/03 00:00 [received]
PHST- 2009/12/11 00:00 [accepted]
PHST- 2010/01/30 06:00 [entrez]
PHST- 2010/01/30 06:00 [pubmed]
PHST- 2010/05/21 06:00 [medline]
PHST- 2010/01/11 00:00 [pmc-release]
AID - 09-PONE-RA-12691R1 [pii]
AID - 10.1371/journal.pone.0008656 [doi]
PST - epublish
SO  - PLoS One. 2010 Jan 11;5(1):e8656. doi: 10.1371/journal.pone.0008656.