PMID- 20111901
OWN - NLM
STAT- MEDLINE
DCOM- 20100916
LR  - 20211020
IS  - 1573-6830 (Electronic)
IS  - 0272-4340 (Linking)
VI  - 30
IP  - 5
DP  - 2010 Jul
TI  - SSeCKS promotes tumor necrosis factor-alpha autocrine via activating p38 and JNK 
      pathways in Schwann cells.
PG  - 701-7
LID - 10.1007/s10571-009-9494-z [doi]
AB  - Tumor necrosis factor-alpha (TNF-alpha) derived from activated Schwann cells 
      (SCs) plays a critical role as an inflammatory mediator in the peripheral nervous 
      system disease. TNF-alpha could act as an autocrine mediator in SC activation. In 
      this study, we found knockdown Src-suppressed protein kinase C substrate (SSeCKS) 
      expression suppressed TNF-alpha production induced by TNF-alpha, overexpression 
      of SSeCKS could promoted TNF-alpha autocrine in SCs. Such effects might be 
      resulted in SSeCKS promoted p38 and JNK activation in SCs treated by TNF-alpha. 
      Thus present data show that while SCs activation, SSeCKS may plays an important 
      role in the release of inflammatory mediators.
FAU - Zhou, Zhengming
AU  - Zhou Z
AD  - Department of Osteology, Affiliated Jiangyin Hospital of Nantong University, and 
      The Jiangsu Province Key Laboratory of Neuroregeneration, Nantong University, 
      Nantong 226001, Jiangsu, People's Republic of China.
FAU - Tao, Tao
AU  - Tao T
FAU - Ji, Yuhong
AU  - Ji Y
FAU - Yang, Huiguang
AU  - Yang H
FAU - Wang, Youhua
AU  - Wang Y
FAU - Cheng, Chun
AU  - Cheng C
FAU - Shen, Aiguo
AU  - Shen A
FAU - Lu, Xiang
AU  - Lu X
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20100129
PL  - United States
TA  - Cell Mol Neurobiol
JT  - Cellular and molecular neurobiology
JID - 8200709
RN  - 0 (A Kinase Anchor Proteins)
RN  - 0 (Akap12 protein, rat)
RN  - 0 (Cell Cycle Proteins)
RN  - 0 (Tumor Necrosis Factor-alpha)
RN  - EC 2.7.11.24 (JNK Mitogen-Activated Protein Kinases)
RN  - EC 2.7.11.24 (p38 Mitogen-Activated Protein Kinases)
SB  - IM
MH  - A Kinase Anchor Proteins/*metabolism
MH  - Animals
MH  - *Autocrine Communication/drug effects
MH  - Cell Cycle Proteins/*metabolism
MH  - Cells, Cultured
MH  - Enzyme Activation/drug effects
MH  - Gene Knockdown Techniques
MH  - JNK Mitogen-Activated Protein Kinases/*metabolism
MH  - *MAP Kinase Signaling System/drug effects
MH  - Phosphorylation/drug effects
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Schwann Cells/drug effects/*enzymology/metabolism
MH  - Tumor Necrosis Factor-alpha/*metabolism/pharmacology
MH  - p38 Mitogen-Activated Protein Kinases/*metabolism
EDAT- 2010/01/30 06:00
MHDA- 2010/09/18 06:00
CRDT- 2010/01/30 06:00
PHST- 2009/09/02 00:00 [received]
PHST- 2009/12/28 00:00 [accepted]
PHST- 2010/01/30 06:00 [entrez]
PHST- 2010/01/30 06:00 [pubmed]
PHST- 2010/09/18 06:00 [medline]
AID - 10.1007/s10571-009-9494-z [doi]
PST - ppublish
SO  - Cell Mol Neurobiol. 2010 Jul;30(5):701-7. doi: 10.1007/s10571-009-9494-z. Epub 
      2010 Jan 29.