PMID- 20112010
OWN - NLM
STAT- MEDLINE
DCOM- 20100421
LR  - 20211020
IS  - 1432-2072 (Electronic)
IS  - 0033-3158 (Linking)
VI  - 209
IP  - 1
DP  - 2010 Mar
TI  - An in vivo microdialysis assessment of concurrent MDMA and cocaine administration 
      in Sprague-Dawley rats.
PG  - 95-102
LID - 10.1007/s00213-009-1774-2 [doi]
AB  - BACKGROUND AND RATIONALE: Despite the popularity of polysubstance abuse among 
      recreational methylendioxymethamphetamine (MDMA) users, relatively few controlled 
      experimental studies have documented the neurobehavioral effects of MDMA in 
      combination with other abused substances. OBJECTIVE: In this study, the combined 
      acute effects of MDMA and cocaine were examined by conducting in vivo 
      microdialysis in the rat nucleus accumbens while simultaneously monitoring 
      locomotor activity. METHODS: Male Sprague-Dawley rats were administered cocaine 
      (10 or 20 mg/kg, i.p.), MDMA (1.5 or 3.0 mg/kg, i.p.), or one of four 
      combinations of cocaine and MDMA during microdialysis experiments. Locomotor 
      activity was monitored, and dialysis samples were collected every 30 min for 3 h 
      prior to injections, for one 30-min period following saline injections, and for 
      an additional 3-h period following drug injections. Samples were analyzed for 
      dopamine content by high-performance liquid chromatography with electrochemical 
      detection. RESULTS: Significant differences in locomotor activity and dopamine 
      efflux were found among treatment groups, with some MDMA/cocaine combinations 
      producing significantly greater increases compared to single doses of cocaine or 
      MDMA within the first 30 min after injection. CONCLUSION: Considering the 
      popularity of polysubstance use among recreational MDMA users, the clinical 
      implications of the current findings warrant further investigation.
FAU - Panos, John J
AU  - Panos JJ
AD  - Department of Psychology, Western Michigan University, Kalamazoo, MI 49008, USA.
FAU - Baker, Lisa E
AU  - Baker LE
LA  - eng
GR  - DA 05018/DA/NIDA NIH HHS/United States
GR  - DA17918/DA/NIDA NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
DEP - 20100130
PL  - Germany
TA  - Psychopharmacology (Berl)
JT  - Psychopharmacology
JID - 7608025
RN  - 0 (Dopamine Uptake Inhibitors)
RN  - 0 (Hallucinogens)
RN  - I5Y540LHVR (Cocaine)
RN  - KE1SEN21RM (N-Methyl-3,4-methylenedioxyamphetamine)
RN  - VTD58H1Z2X (Dopamine)
SB  - IM
MH  - Animals
MH  - Behavior, Animal/*drug effects
MH  - Chromatography, High Pressure Liquid
MH  - Cocaine/administration & dosage/*toxicity
MH  - Dopamine/metabolism
MH  - Dopamine Uptake Inhibitors/administration & dosage/toxicity
MH  - Dose-Response Relationship, Drug
MH  - Drug Interactions
MH  - Hallucinogens/administration & dosage/toxicity
MH  - Male
MH  - Microdialysis
MH  - Motor Activity/*drug effects
MH  - N-Methyl-3,4-methylenedioxyamphetamine/administration & dosage/*toxicity
MH  - Nucleus Accumbens/drug effects/metabolism
MH  - Rats
MH  - Rats, Sprague-Dawley
EDAT- 2010/01/30 06:00
MHDA- 2010/04/22 06:00
CRDT- 2010/01/30 06:00
PHST- 2009/04/06 00:00 [received]
PHST- 2009/12/30 00:00 [accepted]
PHST- 2010/01/30 06:00 [entrez]
PHST- 2010/01/30 06:00 [pubmed]
PHST- 2010/04/22 06:00 [medline]
AID - 10.1007/s00213-009-1774-2 [doi]
PST - ppublish
SO  - Psychopharmacology (Berl). 2010 Mar;209(1):95-102. doi: 
      10.1007/s00213-009-1774-2. Epub 2010 Jan 30.