PMID- 20112301
OWN - NLM
STAT- MEDLINE
DCOM- 20100913
LR  - 20171116
IS  - 1613-4133 (Electronic)
IS  - 1613-4125 (Linking)
VI  - 54 Suppl 1
DP  - 2010 May
TI  - Green tea polyphenols improve cardiac muscle mRNA and protein levels of signal 
      pathways related to insulin and lipid metabolism and inflammation in 
      insulin-resistant rats.
PG  - S14-23
LID - 10.1002/mnfr.200900306 [doi]
AB  - Epidemiological studies indicate that the consumption of green tea polyphenols 
      (GTP) may reduce the risk of coronary artery disease. To explore the underlying 
      mechanisms of action at the molecular level, we examined the effects of GTP on 
      the cardiac mRNA and protein levels of genes involved in insulin and lipid 
      metabolism and inflammation. In rats fed a high-fructose diet, supplementation 
      with GTP (200 mg/kg BW daily dissolved in distilled water) for 6 wk, reduced 
      systemic blood glucose, plasma insulin, retinol-binding protein 4, soluble CD36, 
      cholesterol, triglycerides, free fatty acids and LDL-C levels, as well as the 
      pro-inflammatory cytokines, tumor necrosis factor-alpha (TNF-alpha) and IL-6. GTP 
      did not affect food intake, bodyweight and heart weight. In the myocardium, GTP 
      also increased the insulin receptor (Ir), insulin receptor substrate 1 and 2 
      (Irs1 and Irs2), phosphoinositide-3-kinase (Pi3k), v-akt murine thymoma viral 
      oncogene homolog 1 (Akt1), glucose transporter 1 and 4 (Glut1 and Glut4) and 
      glycogen synthase 1 (Gys1) expression but inhibited phosphatase and tensin 
      homolog deleted on chromosome ten (Pten) expression and decreased glycogen 
      synthase kinase 3beta (Gsk3beta) mRNA expression. The sterol regulatory 
      element-binding protein-1c (Srebp1c) mRNA, microsomal triglyceride transfer 
      protein (Mttp) mRNA and protein, Cd36 mRNA and cluster of differentiation 36 
      protein levels were decreased and peroxisome proliferator-activated receptor 
      (Ppar)gamma mRNA levels were increased. GTP also decreased the inflammatory 
      factors: Tnf, Il1b and Il6 mRNA levels, and enhanced the anti-inflammatory 
      protein, zinc-finger protein, protein and mRNA expression. In summary, 
      consumption of GTP ameliorated the detrimental effects of high-fructose diet on 
      insulin signaling, lipid metabolism and inflammation in the cardiac muscle of 
      rats.
FAU - Qin, Bolin
AU  - Qin B
AD  - Diet, Genomics, and Immunology Laboratory, Beltsville Human Nutrition Research 
      Center, Agricultural Research Service, US Department of Agriculture, Beltsville, 
      MD 20705, USA.
FAU - Polansky, Marilyn M
AU  - Polansky MM
FAU - Harry, Dawson
AU  - Harry D
FAU - Anderson, Richard A
AU  - Anderson RA
LA  - eng
PT  - Journal Article
PT  - Research Support, U.S. Gov't, Non-P.H.S.
PL  - Germany
TA  - Mol Nutr Food Res
JT  - Molecular nutrition & food research
JID - 101231818
RN  - 0 (Blood Glucose)
RN  - 0 (CD36 Antigens)
RN  - 0 (Flavonoids)
RN  - 0 (Insulin)
RN  - 0 (Muscle Proteins)
RN  - 0 (Phenols)
RN  - 0 (Polyphenols)
RN  - 0 (RNA, Messenger)
RN  - 0 (Rbp4 protein, rat)
RN  - 0 (Retinol-Binding Proteins, Plasma)
RN  - 0 (Tea)
RN  - 86-01-1 (Guanosine Triphosphate)
RN  - EC 2.7.11.1 (GSK3B protein, human)
RN  - EC 2.7.11.1 (Glycogen Synthase Kinase 3 beta)
RN  - EC 2.7.11.1 (Gsk3b protein, rat)
RN  - EC 2.7.11.26 (Glycogen Synthase Kinase 3)
SB  - IM
MH  - Animals
MH  - Blood Glucose/metabolism
MH  - Body Weight/drug effects
MH  - CD36 Antigens/blood
MH  - Flavonoids/*pharmacology
MH  - Gene Deletion
MH  - Gene Expression Regulation/drug effects
MH  - Glycogen Synthase Kinase 3/genetics
MH  - Glycogen Synthase Kinase 3 beta
MH  - Guanosine Triphosphate/pharmacology
MH  - Inflammation/prevention & control
MH  - Insulin/blood
MH  - Insulin Resistance/*physiology
MH  - Muscle Proteins/*metabolism
MH  - Myocardium/*metabolism
MH  - Organ Size/drug effects
MH  - Phenols/*pharmacology
MH  - Polyphenols
MH  - RNA, Messenger/*genetics/metabolism
MH  - Rats
MH  - Retinol-Binding Proteins, Plasma/metabolism
MH  - *Tea
EDAT- 2010/01/30 06:00
MHDA- 2010/09/14 06:00
CRDT- 2010/01/30 06:00
PHST- 2010/01/30 06:00 [entrez]
PHST- 2010/01/30 06:00 [pubmed]
PHST- 2010/09/14 06:00 [medline]
AID - 10.1002/mnfr.200900306 [doi]
PST - ppublish
SO  - Mol Nutr Food Res. 2010 May;54 Suppl 1:S14-23. doi: 10.1002/mnfr.200900306.