PMID- 20112804
OWN - NLM
STAT- MEDLINE
DCOM- 20100218
LR  - 20100201
IS  - 0019-5189 (Print)
IS  - 0019-5189 (Linking)
VI  - 47
IP  - 10
DP  - 2009 Oct
TI  - Comparative genomic hybridization array study and its utility in detection of 
      constitutional and acquired anomalies.
PG  - 779-91
AB  - The last decade has witnessed an upsurge in the knowledge of cytogenetic 
      disorders and putting the old technology in a new basket with molecular genetics. 
      As conventional cytogenetic can detect the genetic alteration of 10-15 Mb, many 
      of the micro-deletions and micro-duplications are missed. However, with the 
      advent of technology of fluorescence in situ hybridization (FISH), the resolution 
      of genetic aberrations can reach to 3-5 Mb, nonetheless the anomalies smaller 
      than the above, need further precision which has been achieved using comparative 
      genomic hybridization array (CGH-array). Introduction of array-CGH has brought 
      higher sensitivity with automated DNA fragment analyzer and DNA chip for 
      submicroscopic chromosomal anomalies that are missed till date in many of the 
      acquired and constitutional genetic disorders. The resolution of the technology 
      varies from several Kb to 1 Mb depending upon the type of array selected. With 
      the recent improvement in the array-CGH technology, a link between cytogenetic 
      and molecular biology has been established without replacing conventional 
      cytogenetic technique. The wider accessibility of the technology shall certainly 
      provide a clue to the many unidentified/unexplained genetic disorders which shall 
      prove to be a boon to the clinicians.
FAU - Andrieux, Joris
AU  - Andrieux J
AD  - Laboratory of Medical Genetics, Jeanne de Flandre Hospital CHRU de Lille, Lille 
      Cedex, France.
FAU - Sheth, Frenny
AU  - Sheth F
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - India
TA  - Indian J Exp Biol
JT  - Indian journal of experimental biology
JID - 0233411
SB  - IM
MH  - Congenital Abnormalities/*diagnosis/genetics
MH  - *Genomics
MH  - Humans
MH  - In Situ Hybridization, Fluorescence
MH  - Karyotyping
MH  - *Nucleic Acid Hybridization
RF  - 117
EDAT- 2010/02/02 06:00
MHDA- 2010/02/19 06:00
CRDT- 2010/02/02 06:00
PHST- 2010/02/02 06:00 [entrez]
PHST- 2010/02/02 06:00 [pubmed]
PHST- 2010/02/19 06:00 [medline]
PST - ppublish
SO  - Indian J Exp Biol. 2009 Oct;47(10):779-91.