PMID- 20113121
OWN - NLM
STAT- MEDLINE
DCOM- 20100412
LR  - 20240511
IS  - 1089-7623 (Electronic)
IS  - 0034-6748 (Print)
IS  - 0034-6748 (Linking)
VI  - 81
IP  - 1
DP  - 2010 Jan
TI  - Development of a catheter for combined intravascular ultrasound and photoacoustic 
      imaging.
PG  - 014901
LID - 10.1063/1.3274197 [doi]
LID - 014901
AB  - Atherosclerosis is characterized by formation and development of the plaques in 
      the inner layer of the vessel wall. To detect and characterize atherosclerotic 
      plaques, we previously introduced the combined intravascular ultrasound (IVUS) 
      and intravascular photoacoustic (IVPA) imaging capable of assessing plaque 
      morphology and composition. The utility of IVUS/IVPA imaging has been 
      demonstrated by imaging tissue-mimicking phantoms and ex vivo arterial samples 
      using laboratory prototype of the imaging system. However, the clinical 
      realization of a IVUS/IVPA imaging requires an integrated intravascular imaging 
      catheter. In this paper, two designs of IVUS/IVPA imaging catheters--side fire 
      fiber-based and mirror-based catheters--are reported. A commercially available 
      IVUS imaging catheter was utilized for both pulse-echo ultrasound imaging and 
      detection of photoacoustic transients. Laser pulses were delivered by 
      custom-designed fiber-based optical systems. The optical fiber and IVUS imaging 
      catheter were combined into a single device. Both designs were tested and 
      compared using point targets and tissue-mimicking phantoms. The results indicate 
      applicability of the proposed catheters for clinical use.
FAU - Karpiouk, Andrei B
AU  - Karpiouk AB
AD  - Department of Biomedical Engineering, University of Texas at Austin, 1 University 
      Station C0800, Austin, Texas 78712, USA.
FAU - Wang, Bo
AU  - Wang B
FAU - Emelianov, Stanislav Y
AU  - Emelianov SY
LA  - eng
GR  - R01 HL096981/HL/NHLBI NIH HHS/United States
GR  - R21 HL084076/HL/NHLBI NIH HHS/United States
GR  - HL 084076/HL/NHLBI NIH HHS/United States
GR  - HL 096981/HL/NHLBI NIH HHS/United States
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PL  - United States
TA  - Rev Sci Instrum
JT  - The Review of scientific instruments
JID - 0405571
SB  - IM
MH  - Acoustics/*instrumentation
MH  - Algorithms
MH  - Catheterization/*instrumentation
MH  - Equipment Design
MH  - Fiber Optic Technology/*instrumentation
MH  - Humans
MH  - Lasers
MH  - Light
MH  - Models, Biological
MH  - *Optical Devices
MH  - Phantoms, Imaging
MH  - Ultrasonography, Interventional/*instrumentation/methods
PMC - PMC2814830
EDAT- 2010/02/02 06:00
MHDA- 2010/04/13 06:00
PMCR- 2011/01/01
CRDT- 2010/02/02 06:00
PHST- 2010/02/02 06:00 [entrez]
PHST- 2010/02/02 06:00 [pubmed]
PHST- 2010/04/13 06:00 [medline]
PHST- 2011/01/01 00:00 [pmc-release]
AID - 054912RSI [pii]
AID - 10.1063/1.3274197 [doi]
PST - ppublish
SO  - Rev Sci Instrum. 2010 Jan;81(1):014901. doi: 10.1063/1.3274197.