PMID- 20118559
OWN - NLM
STAT- MEDLINE
DCOM- 20100903
LR  - 20190720
IS  - 1347-5215 (Electronic)
IS  - 0918-6158 (Linking)
VI  - 33
IP  - 2
DP  - 2010
TI  - Effects of proteoglycan extracted from nasal cartilage of salmon heads on 
      maturation of dendritic cells derived from human peripheral blood monocytes.
PG  - 311-5
AB  - Dendritic cells (DCs) play an essential role in the immune system. The transition 
      from immature DC (iDCs) to mature DCs (mDCs) requires appropriate stimuli such as 
      pro-inflammatory cytokines. Proteoglycans (PGs) are one of the main components of 
      extracellular matrix, and some types of PGs are known to induce maturation of 
      murine DCs. Recent studies have investigated the potential benefits of PG from 
      nasal cartilage of salmon head (S-PG). This study investigated the effects of 
      S-PG on maturation of human monocyte-derived DCs. iDCs were prepared from human 
      monocytes using the appropriate cytokines and then stimulated by S-PG alone. In 
      another experiment, iDCs were stimulated by a combination of pro-inflammatory 
      cytokines (MIX) plus S-PG. Although the stimulation of S-PG alone did not induce 
      phenotypic maturation from iDCs, CD40 expression on DCs stimulated by S-PG alone 
      was lower than that of iDCs. In contrast, the phenotypic and functional 
      characteristics of DCs stimulated by MIX+S-PG were similar to those of DCs 
      stimulated by MIX alone. As a result, S-PG did not demonstrate a significant 
      effect with regard to maturation of human monocyte-derived DCs.
FAU - Yoshino, Hironori
AU  - Yoshino H
AD  - Department of Radiological Life Sciences, Division of Medical Life Sciences, 
      Hirosaki University Graduate School of Health Sciences, 66-1 Hon-cho, Hirosaki, 
      Aomori 036-8564, Japan.
FAU - Takahashi, Kenji
AU  - Takahashi K
FAU - Monzen, Satoru
AU  - Monzen S
FAU - Kashiwakura, Ikuo
AU  - Kashiwakura I
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Japan
TA  - Biol Pharm Bull
JT  - Biological & pharmaceutical bulletin
JID - 9311984
RN  - 0 (Proteoglycans)
RN  - 0 (Recombinant Proteins)
SB  - IM
MH  - Animals
MH  - Cell Differentiation/*drug effects
MH  - Cells, Cultured
MH  - Dendritic Cells/cytology/*drug effects/*physiology
MH  - Humans
MH  - Leukocytes, Mononuclear/cytology/*drug effects/*physiology
MH  - Nasal Cartilages/*chemistry
MH  - Proteoglycans/isolation & purification/*pharmacology
MH  - Recombinant Proteins/isolation & purification/pharmacology
MH  - Salmon
EDAT- 2010/02/02 06:00
MHDA- 2010/09/04 06:00
CRDT- 2010/02/02 06:00
PHST- 2010/02/02 06:00 [entrez]
PHST- 2010/02/02 06:00 [pubmed]
PHST- 2010/09/04 06:00 [medline]
AID - JST.JSTAGE/bpb/33.311 [pii]
AID - 10.1248/bpb.33.311 [doi]
PST - ppublish
SO  - Biol Pharm Bull. 2010;33(2):311-5. doi: 10.1248/bpb.33.311.