PMID- 20119648
OWN - NLM
STAT- MEDLINE
DCOM- 20100929
LR  - 20211020
IS  - 1432-1459 (Electronic)
IS  - 0340-5354 (Linking)
VI  - 257
IP  - 6
DP  - 2010 Jun
TI  - Olfactory dysfunction and cardiovascular dysautonomia in Parkinson's disease.
PG  - 969-76
LID - 10.1007/s00415-009-5447-1 [doi]
AB  - Several studies have reported that olfactory dysfunction is an early 
      neuropathological manifestation of Parkinson's disease (PD). Reduced cardiac 
      meta-iodobenzylguanidine ((123)I-MIBG) uptake may be one of the earliest signs of 
      PD. We studied the relation of olfactory dysfunction to cardiovascular 
      dysautonomia in patients with PD. The study group comprised 66 patients with PD 
      (70.5 years) and 26 controls (70.3 years) for olfactory assessment, 21 controls 
      (72.1 years) for cardiac (123)I-MIBG scintigraphy and heart rate variability 
      (HRV), assessed using the coefficient of variation for RR intervals (HRV), and 23 
      controls (69.2 years) for orthostatic blood pressure response. Olfactory function 
      was assessed by the odor stick identification test Japan (OSIT-J), and 
      cardiovascular autonomic function was evaluated by (123)I-MIBG scintigraphy of 
      the heart, the fall in orthostatic blood pressure, and HRV. Patients with PD had 
      a significantly lower OSIT-J score than did the controls (4.1 +/- 3.0 vs. 9.9 +/- 
      1.7, p = 0.001). The OSIT-J score was unrelated to variables other than gender, 
      including age, disease duration, motor score on the unified Parkinson's disease 
      rating scale, score on the mini-mental state examination, motor phenotype, visual 
      hallucinations, and dopaminergic medication on multiple regression and logistic 
      regression analyses. The OSIT-J score was related to the heart/mediastinum ratio 
      of cardiac (123)I-MIBG uptake, the fall in orthostatic blood pressure, and HRV, 
      after adjustment for other clinical variables. Olfactory dysfunction in PD was, 
      thus, significantly related to both cardiac sympathetic and parasympathetic 
      dysfunction, as well as vascular sympathetic dysfunction. As non-motor symptoms 
      of PD, olfactory dysfunction and autonomic network failure appear to be closely 
      related in PD.
FAU - Oka, Hisayoshi
AU  - Oka H
AD  - Department of Neurology, Daisan Hospital, The University School of Medicine, 
      4-11-1, Izumihoncho, Komae, Tokyo 201-8601, Japan. h.oka@jikei.ac.jp
FAU - Toyoda, Chizuko
AU  - Toyoda C
FAU - Yogo, Makiko
AU  - Yogo M
FAU - Mochio, Soichiro
AU  - Mochio S
LA  - eng
PT  - Journal Article
DEP - 20100130
PL  - Germany
TA  - J Neurol
JT  - Journal of neurology
JID - 0423161
RN  - 35MRW7B4AD (3-Iodobenzylguanidine)
SB  - IM
MH  - 3-Iodobenzylguanidine
MH  - Aged
MH  - Aged, 80 and over
MH  - Blood Pressure
MH  - Cardiovascular Diseases/*complications/diagnostic imaging/physiopathology
MH  - Case-Control Studies
MH  - Female
MH  - Heart/diagnostic imaging
MH  - Heart Rate
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Odorants
MH  - Olfaction Disorders/*complications/physiopathology
MH  - Parkinson Disease/*complications/diagnostic imaging/physiopathology
MH  - Pattern Recognition, Physiological
MH  - Physical Stimulation
MH  - Primary Dysautonomias/*complications/diagnostic imaging/physiopathology
MH  - Radionuclide Imaging
MH  - Severity of Illness Index
MH  - Sex Factors
EDAT- 2010/02/02 06:00
MHDA- 2010/09/30 06:00
CRDT- 2010/02/02 06:00
PHST- 2009/08/15 00:00 [received]
PHST- 2009/12/28 00:00 [accepted]
PHST- 2009/12/17 00:00 [revised]
PHST- 2010/02/02 06:00 [entrez]
PHST- 2010/02/02 06:00 [pubmed]
PHST- 2010/09/30 06:00 [medline]
AID - 10.1007/s00415-009-5447-1 [doi]
PST - ppublish
SO  - J Neurol. 2010 Jun;257(6):969-76. doi: 10.1007/s00415-009-5447-1. Epub 2010 Jan 
      30.