PMID- 2011983 OWN - NLM STAT- MEDLINE DCOM- 19910503 LR - 20190622 IS - 0002-9149 (Print) IS - 0002-9149 (Linking) VI - 67 IP - 9 DP - 1991 Apr 15 TI - Comparison of intravascular ultrasound, external ultrasound and digital angiography for evaluation of peripheral artery dimensions and morphology. PG - 817-22 AB - Validation of catheter-based intravascular ultrasound imaging has been based on comparisons with histology and digital angiography, each of which may have limitations in the assessment of arterial size and morphology. External, high-frequency ultrasound can accurately determine vessel dimensions and morphology and because, like ultravascular ultrasound, it also provides cross-sectional arterial ultrasound images, it may be a more appropriate technique for the in vivo comparison of arterial dimensions and morphology determined by intravascular ultrasound. Thus, intravascular ultrasound, external 2-dimensional ultrasound, Doppler color-flow imaging and digital angiography were compared for assessment of arterial dimensions and wall morphology at 29 femoral artery sites in 15 patients. Intravascular ultrasound and the other 3 imaging modalities correlated well in determination of lumen diameter (2-dimensional, r = 0.98, standard error of the estimate [SEE] = 0.14; Doppler color flow, r = 0.91, SEE = 1.11; angiography, r = 0.95, SEE = 0.91) and cross-sectional area (2-dimensional, r = 0.97, SEE = 0.04; Doppler color flow, r = 0.92, SEE = 0.14; angiography, r = 0.96, SEE = 0.08). However, lumen size measured by Doppler color flow was consistently smaller than that measured by the other 3 imaging modalities. Intravascular ultrasound detected arterial plaque at 15 sites, 5 of which were hypoechoic (soft) and 10 hyperechoic with distal shadowing (hard). Plaque was identified at 12 of 15 sites by Z-dimensional imaging (p = 0.30 vs intravascular ultrasound), but at only 6 of 15 sites by angiography (p = 0.003 vs intravascular ultrasound), only 1 of which was thought to be calcified plaque.(ABSTRACT TRUNCATED AT 250 WORDS) FAU - Sheikh, K H AU - Sheikh KH AD - Department of Medicine, Duke University Medical Center, Durham, North Carolina 27710. FAU - Davidson, C J AU - Davidson CJ FAU - Kisslo, K B AU - Kisslo KB FAU - Harrison, J K AU - Harrison JK FAU - Himmelstein, S I AU - Himmelstein SI FAU - Kisslo, J AU - Kisslo J FAU - Bashore, T M AU - Bashore TM LA - eng GR - CA-37586/CA/NCI NIH HHS/United States PT - Comparative Study PT - Journal Article PT - Research Support, U.S. Gov't, P.H.S. PL - United States TA - Am J Cardiol JT - The American journal of cardiology JID - 0207277 SB - IM MH - Adult MH - Aged MH - *Angiography, Digital Subtraction MH - Arteriosclerosis/diagnostic imaging MH - Catheterization, Peripheral MH - Color MH - Doppler Effect MH - Female MH - Femoral Artery/anatomy & histology/*diagnostic imaging MH - Humans MH - Image Processing, Computer-Assisted MH - Male MH - Methods MH - Middle Aged MH - Ultrasonography MH - Videotape Recording EDAT- 1991/04/15 00:00 MHDA- 1991/04/15 00:01 CRDT- 1991/04/15 00:00 PHST- 1991/04/15 00:00 [pubmed] PHST- 1991/04/15 00:01 [medline] PHST- 1991/04/15 00:00 [entrez] AID - 0002-9149(91)90613-P [pii] AID - 10.1016/0002-9149(91)90613-p [doi] PST - ppublish SO - Am J Cardiol. 1991 Apr 15;67(9):817-22. doi: 10.1016/0002-9149(91)90613-p.