PMID- 20119856
OWN - NLM
STAT- MEDLINE
DCOM- 20101007
LR  - 20211020
IS  - 1863-4362 (Electronic)
IS  - 0021-1265 (Linking)
VI  - 179
IP  - 2
DP  - 2010 Jun
TI  - Haplotype association of calpain 10 gene variants with type 2 diabetes mellitus 
      in an Irish sample.
PG  - 269-72
LID - 10.1007/s11845-010-0462-x [doi]
AB  - BACKGROUND: Calpain 10 (CAPN10) gene may contribute to the pathogenesis of type 2 
      diabetes mellitus (T2DM). AIM: To examine the contribution of four CAPN10 gene 
      variants to T2DM risk in an Irish sample. METHODS: Genotyping of marker 19 
      insertion-deletion (ins/del) and three CAPN10 variants, rs3792267, rs3749166 and 
      rs5030952 at the CAPN10 gene was performed in 236 T2DM subjects and 120 controls. 
      Allelic, genotypic and haplotype comparisons were conducted between the groups. 
      RESULTS: In the examined markers, no significant differences were observed 
      although the deletion/deletion allele tended to be more common in T2DM subjects 
      (chi(2) = 3.2, P = 0.07). A significant overrepresentation of a haplotype 
      comprising (rs3792267), (19) and rs3749166 (chi(2) = 5.3, P = 0.021) was seen in 
      T2DM subjects. Two protective haplotypes were detected: (G-ins-G) of (rs3792267), 
      (19) and rs3749166 (chi(2) = 6.7, P = 0.009) and (ins-G-C) of (19), (rs3749166) 
      and rs5030952 (chi(2) = 8.5, P = 0.003). CONCLUSIONS: CAPN10 gene variants may 
      affect T2DM susceptibility in the Irish population.
FAU - Alsaraj, F
AU  - Alsaraj F
AD  - Department of Endocrinology, Connolly Hospital, Blanchardstwon, Dublin 15, 
      Ireland. fuadsaraj@hotmail.com
FAU - O'Gorman, D
AU  - O'Gorman D
FAU - McAteer, S
AU  - McAteer S
FAU - McDermott, J
AU  - McDermott J
FAU - Hawi, Z
AU  - Hawi Z
FAU - Sreenan, S
AU  - Sreenan S
LA  - eng
PT  - Journal Article
DEP - 20100202
PL  - Ireland
TA  - Ir J Med Sci
JT  - Irish journal of medical science
JID - 7806864
RN  - 0 (Genetic Markers)
RN  - EC 3.4.22.- (Calpain)
RN  - EC 3.4.22.- (calpain 10)
SB  - IM
MH  - Alleles
MH  - Calpain/*genetics
MH  - Case-Control Studies
MH  - Diabetes Mellitus, Type 2/epidemiology/*genetics/physiopathology
MH  - Female
MH  - Gene Deletion
MH  - Gene Frequency
MH  - Genetic Markers
MH  - Genetic Variation
MH  - Genotype
MH  - Haplotypes/*genetics
MH  - Humans
MH  - Ireland/epidemiology
MH  - Linkage Disequilibrium
MH  - Male
MH  - Middle Aged
MH  - Odds Ratio
MH  - Polymorphism, Genetic
EDAT- 2010/02/02 06:00
MHDA- 2010/10/12 06:00
CRDT- 2010/02/02 06:00
PHST- 2009/02/11 00:00 [received]
PHST- 2010/01/03 00:00 [accepted]
PHST- 2010/02/02 06:00 [entrez]
PHST- 2010/02/02 06:00 [pubmed]
PHST- 2010/10/12 06:00 [medline]
AID - 10.1007/s11845-010-0462-x [doi]
PST - ppublish
SO  - Ir J Med Sci. 2010 Jun;179(2):269-72. doi: 10.1007/s11845-010-0462-x. Epub 2010 
      Feb 2.