PMID- 20120870
OWN - NLM
STAT- MEDLINE
DCOM- 20110609
LR  - 20100203
IS  - 2096-7993 (Print)
IS  - 2096-7993 (Linking)
VI  - 23
IP  - 19
DP  - 2009 Oct
TI  - [The expression stathmin gene in laryngeal squamous cell carcinoma].
PG  - 872-3, 877
AB  - OBJECTIVE: To observe expression of stathmin gene in laryngeal squamous cell 
      carcinoma (LSCC) and relation between expression of stathmin gene and occurrence 
      and development of LSCC. METHOD: The expression of the stathmin gene was 
      determined in 35 LSCC of specimens and 18 normal laryngeal tissues (NLT) of 
      specimens by in situ hybridization with Digoxigenin labeled probe of stathmin 
      mRNA. RESULT: Expression of stathmin gene was observed in 35 cases of laryngeal 
      squamous cell carcinoma tissue (positive rate, 69%) and positive signal was 
      observed in both cytoplasm and nuclear. Among 18 cases of normal tissue, only 6 
      showed weak positive signal. There was significant difference in expression of 
      stathmin gene between laryngeal squamous cell carcinoma tissue and normal tissue. 
      CONCLUSION: Expression of stathmin gene may play a key role in the pathogenesis 
      and development of laryngeal squamous cell carcinoma. It may be a very important 
      biotherapy target in the treatment of laryngeal squamous cell carcinoma.
FAU - Zhang, Xuecong
AU  - Zhang X
AD  - Department of Otolaryngology, the First Affiliated Hospital of Zhengzhou 
      University, Zhengzhou, Henan, 450052, China.
FAU - Cao, Hua
AU  - Cao H
FAU - Gao, Dongling
AU  - Gao D
LA  - chi
PT  - English Abstract
PT  - Journal Article
PL  - China
TA  - Lin Chuang Er Bi Yan Hou Tou Jing Wai Ke Za Zhi
JT  - Lin chuang er bi yan hou tou jing wai ke za zhi = Journal of clinical 
      otorhinolaryngology, head, and neck surgery
JID - 101303164
RN  - 0 (RNA, Messenger)
RN  - 0 (STMN1 protein, human)
RN  - 0 (Stathmin)
SB  - IM
MH  - Carcinoma, Squamous Cell/*genetics/metabolism/pathology
MH  - Gene Expression
MH  - Humans
MH  - Laryngeal Neoplasms/*genetics/metabolism/pathology
MH  - RNA, Messenger/genetics
MH  - Stathmin/genetics/*metabolism
EDAT- 2010/02/04 06:00
MHDA- 2011/06/10 06:00
CRDT- 2010/02/04 06:00
PHST- 2010/02/04 06:00 [entrez]
PHST- 2010/02/04 06:00 [pubmed]
PHST- 2011/06/10 06:00 [medline]
PST - ppublish
SO  - Lin Chuang Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2009 Oct;23(19):872-3, 877.