PMID- 20121262
OWN - NLM
STAT- MEDLINE
DCOM- 20100908
LR  - 20100526
IS  - 1520-5827 (Electronic)
IS  - 0743-7463 (Linking)
VI  - 26
IP  - 11
DP  - 2010 Jun 1
TI  - Controlling the particle size of interpolymer complexes through host-guest 
      interaction for drug delivery.
PG  - 9011-6
LID - 10.1021/la9048133 [doi]
AB  - A new method to adjust the particle size of interpolymer complexes has been 
      developed by introduction of host-guest interaction into the dilute aqueous 
      solution of poly(acrylic acid) (PAA) and poly(ethylene glycol) (PEG). Because of 
      the cooperative hydrogen-bonding interaction, PAA can form the interpolymer 
      complexes with PEG. Putting beta-cyclodextrin (beta-CD) into dilute PAA/PEG 
      aqueous solution, the competition between host-guest and hydrogen-bonding 
      interactions happens. The beta-CD/PAA/PEG ternary systems have been well 
      characterized by ultraviolet-visible absorption spectroscopy (UV-vis), dynamic 
      light scattering (DLS), transmission electron microscopy (TEM), diffusion NMR 
      spectroscopy, attenuated total reflectance-Fourier transform infrared (ATR-FTIR), 
      and solid-state (13)C NMR spectroscopy. The results indicate that the hydrophobic 
      cavity of beta-CD is threaded by linear polymers so that the hydrophilicity of 
      PAA/PEG interpolymer complexes is improved greatly. Adjusting the amounts of 
      beta-CD, the particle size of the interpolymer complexes can be readily 
      controlled. The low cytotoxicity of various beta-CD/PAA/PEG ternary complexes has 
      been confirmed using the MTT assay in COS-7 cell line. Doxorubicin (DOX), an 
      anticancer drug, has been encapsulated into the beta-CD/PAA/PEG ternary 
      complexes. The DOX-loaded beta-CD/PAA/PEG ternary complexes have been analyzed by 
      confocal laser scanning microscopy (CLSM), flow cytometry analysis, and the MTT 
      assay against human cervical carcinoma cell (Hela). The results indicate that 
      beta-CD/PAA/PEG ternary complexes with controlled particle size could be used as 
      safe and promising drug carriers.
FAU - Chen, Yan
AU  - Chen Y
AD  - School of Chemistry and Chemical Engineering, State Key Laboratory of Metal 
      Matrix Composites, Shanghai Jiao Tong University, 800 Dongchuan Road, Shanghai 
      200240, People's Republic of China.
FAU - Pang, Yan
AU  - Pang Y
FAU - Wu, Jieli
AU  - Wu J
FAU - Su, Yue
AU  - Su Y
FAU - Liu, Jinyao
AU  - Liu J
FAU - Wang, Ruibin
AU  - Wang R
FAU - Zhu, Bangshang
AU  - Zhu B
FAU - Yao, Yefeng
AU  - Yao Y
FAU - Yan, Deyue
AU  - Yan D
FAU - Zhu, Xinyuan
AU  - Zhu X
FAU - Chen, Qun
AU  - Chen Q
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Langmuir
JT  - Langmuir : the ACS journal of surfaces and colloids
JID - 9882736
RN  - 0 (Polymers)
SB  - IM
MH  - *Drug Delivery Systems
MH  - Microscopy, Electron, Transmission
MH  - Particle Size
MH  - Polymers/*chemistry
MH  - Spectroscopy, Fourier Transform Infrared
EDAT- 2010/02/04 06:00
MHDA- 2010/09/09 06:00
CRDT- 2010/02/04 06:00
PHST- 2010/02/04 06:00 [entrez]
PHST- 2010/02/04 06:00 [pubmed]
PHST- 2010/09/09 06:00 [medline]
AID - 10.1021/la9048133 [doi]
PST - ppublish
SO  - Langmuir. 2010 Jun 1;26(11):9011-6. doi: 10.1021/la9048133.