PMID- 20121409
OWN - NLM
STAT- MEDLINE
DCOM- 20100414
LR  - 20100203
IS  - 1557-8976 (Electronic)
IS  - 0882-8245 (Linking)
VI  - 23
IP  - 1
DP  - 2010 Feb
TI  - Serum IL-18 and IL-18BP levels in patients with Chikungunya virus infection.
PG  - 113-7
LID - 10.1089/vim.2009.0077 [doi]
AB  - Chikungunya virus infection has recently emerged in several countries. The 
      inflammatory response is suggested to be involved in the pathology observed in 
      this infectious disease. Interleukin-18 (IL-18) is an inducer of interferon-gamma 
      (IFN-gamma) production and has been shown to play a role in several inflammatory 
      diseases. IL-18 binding protein (IL-18BP) is a natural regulator of IL-18. In 
      this study, we determined the levels of IL-18 and IL-18BP in patients with 
      Chikungunya virus infection. Acute and convalescent sera were collected from each 
      patient. The levels of both IL-18 and IL-18BP were measured by ELISA assays. 
      IL-18 and IL-18BP levels were higher in patients than in controls. In addition, 
      the level of IL-18 was higher in convalescent than in acute sera. However, the 
      level of IL-18BP was lower in convalescent than in acute sera. These data suggest 
      that production of both IL-18 and IL-18BP was induced following Chikungunya virus 
      infection. IL-18BP was increased to regulate the activity of IL-18. The ratio of 
      IL-18 to IL-18BP was higher in convalescent than in acute sera. The lower level 
      of IL-18BP in convalescent sera was probably due to loss following IL-18 
      neutralization. Our data suggest that Chikungunya virus infection promotes the T 
      helper-1 (Th-1) response by inducing IL-18 production. Manipulation of IL-18 and 
      IL-18BP levels could be a promising therapeutic approach to alleviate symptoms in 
      patients with Chikungunya virus infection.
FAU - Chirathaworn, Chintana
AU  - Chirathaworn C
AD  - Department of Microbiology, Faculty of Medicine, Chulalongkorn University, 
      Bangkok, Thailand.
FAU - Rianthavorn, Pornpimol
AU  - Rianthavorn P
FAU - Wuttirattanakowit, Norra
AU  - Wuttirattanakowit N
FAU - Poovorawan, Yong
AU  - Poovorawan Y
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Viral Immunol
JT  - Viral immunology
JID - 8801552
RN  - 0 (Intercellular Signaling Peptides and Proteins)
RN  - 0 (Interleukin-18)
RN  - 0 (interleukin-18 binding protein)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Alphavirus Infections/*immunology/*virology
MH  - Chikungunya virus/*immunology
MH  - Child
MH  - Child, Preschool
MH  - Enzyme-Linked Immunosorbent Assay/methods
MH  - Female
MH  - Follow-Up Studies
MH  - Humans
MH  - Intercellular Signaling Peptides and Proteins/*blood
MH  - Interleukin-18/*blood
MH  - Male
MH  - Middle Aged
MH  - Young Adult
EDAT- 2010/02/04 06:00
MHDA- 2010/04/15 06:00
CRDT- 2010/02/04 06:00
PHST- 2010/02/04 06:00 [entrez]
PHST- 2010/02/04 06:00 [pubmed]
PHST- 2010/04/15 06:00 [medline]
AID - 10.1089/vim.2009.0077 [doi]
PST - ppublish
SO  - Viral Immunol. 2010 Feb;23(1):113-7. doi: 10.1089/vim.2009.0077.