PMID- 20121548
OWN - NLM
STAT- MEDLINE
DCOM- 20100222
LR  - 20100203
IS  - 1532-4192 (Electronic)
IS  - 0735-7907 (Linking)
VI  - 28
IP  - 2
DP  - 2010 Feb
TI  - TERC telomerase subunit gene copy number in different disease stages of 
      non-hodgkin lymphoma and in hepatitis C.
PG  - 181-5
LID - 10.3109/07357900903095748 [doi]
AB  - ABSTRACT Focal amplification of specific regions of the genome creates high copy 
      number and expression of oncogenes in tumors. By applying fluorescence in situ 
      hybridization (FISH) to leukocytes of hepatitis C (HCV) patients and non-Hodgkin 
      lymphoma (NHL) patients, we estimated gene dosage of the TERC gene at 3q26.3. 
      Higher TERC copy numbers were found in NHL at diagnosis compared to HCV patient 
      groups. Higher TERC copy numbers were also observed in NHL patient at diagnosis 
      and relapse compared to patients in remission. We believe that the TERC gene 
      amplification is involved in the process of genetic instability leading to tumor 
      genesis such as in NHL.
FAU - Goldberg-Bittman, L
AU  - Goldberg-Bittman L
AD  - Genetic Institute, Meir Hospital, Kfar Saba 44281, Israel.
FAU - Kitay-Cohen, Y
AU  - Kitay-Cohen Y
FAU - Fejgin, M D
AU  - Fejgin MD
FAU - Hadary, R
AU  - Hadary R
FAU - Quitt, M
AU  - Quitt M
FAU - Amiel, A
AU  - Amiel A
LA  - eng
PT  - Journal Article
PL  - England
TA  - Cancer Invest
JT  - Cancer investigation
JID - 8307154
RN  - 0 (telomerase RNA)
RN  - 63231-63-0 (RNA)
RN  - EC 2.7.7.49 (Telomerase)
SB  - IM
MH  - Aged
MH  - Chromosomes, Human, Pair 3
MH  - *Gene Dosage
MH  - Hepatitis C/*genetics
MH  - Humans
MH  - Lymphoma, Non-Hodgkin/*genetics
MH  - Middle Aged
MH  - RNA/*genetics
MH  - Telomerase/*genetics
EDAT- 2010/02/04 06:00
MHDA- 2010/02/23 06:00
CRDT- 2010/02/04 06:00
PHST- 2010/02/04 06:00 [entrez]
PHST- 2010/02/04 06:00 [pubmed]
PHST- 2010/02/23 06:00 [medline]
AID - 10.3109/07357900903095748 [doi]
PST - ppublish
SO  - Cancer Invest. 2010 Feb;28(2):181-5. doi: 10.3109/07357900903095748.