PMID- 20122372
OWN - NLM
STAT- MEDLINE
DCOM- 20100823
LR  - 20100729
IS  - 1555-2101 (Electronic)
IS  - 0160-6689 (Linking)
VI  - 71
IP  - 7
DP  - 2010 Jul
TI  - The effect of moderate and excessive alcohol use on the course and outcome of 
      patients with bipolar disorders: a prospective cohort study.
PG  - 885-93
LID - 10.4088/JCP.09m05079gry [doi]
AB  - OBJECTIVE: Comorbid alcohol use disorders (AUDs) are frequently associated with 
      negative effects on course and outcome of bipolar disorder. This prospective 
      cohort study assessed the effect of actual alcohol use (no, moderate, and 
      excessive) on the course and outcome of patients with bipolar disorders. METHOD: 
      Between June 2003 and November 2005, 137 outpatients (aged 23-68 years) with 
      DSM-IV-diagnosed bipolar I (66%) or II (34%) disorder rated their mood and the 
      number of alcohol units consumed daily for a period up to 52 weeks with the 
      National Institute of Mental Health Self-Rating Prospective Life-Chart Method 
      (LCM). At baseline, the Structured Clinical Interview for DSM-IV was 
      administrated, and demographic, social, and clinical characteristics were 
      obtained. At monthly visits, the Clinical Global Impressions Scale-Bipolar 
      Version (CGI-BP), the Global Assessment of Functioning (GAF) scale, and the 
      Medical Outcomes Study 36-Item Short-Form Health Survey (MOS-SF-36) were rated. 
      Based on the alcohol use in the first 4 weeks of follow-up, patients were 
      assigned to 1 of 3 groups: no/incidental, moderate, or excessive alcohol use. 
      RESULTS: None of the sociodemographic and clinical characteristics at baseline 
      were significantly different between the 3 drinking groups, with the exception 
      of-and as a consequence of the group assignment-the prevalence of lifetime and 
      current diagnosis of AUD. Also, no differences between the 3 drinking groups were 
      found on any of the clinical outcome variables, ie, number of days ill 
      (depressed, hypomanic/manic, and total); severity of depression, mania, and 
      overall bipolar illness (LCM); GAF score; CGI-BP (depression, mania, and 
      overall); and all the subscales of the MOS-SF-36. Also, the number of episodes 
      according to DSM-IV and the Leapfrog method showed no significant differences 
      between the drinking groups. CONCLUSIONS: In this sample of patients and with the 
      sensitive measurement of mood and drinking status over a full year, we could not 
      confirm the findings of other studies indicating a negative effect of excessive 
      alcohol use on the course of bipolar illness. This study found that neither 
      moderate nor excessive use of alcohol has a negative effect on the course and 
      outcome of bipolar illness. Possible explanations for these findings are 
      discussed.
CI  - (c) Copyright 2010 Physicians Postgraduate Press, Inc.
FAU - van Zaane, J
AU  - van Zaane J
AD  - Department of Psychiatry, EMGO Institute for Health and Care Research, Vrije 
      Universiteit, University Medical Center Amsterdam, Bennebroek, Amsterdam, The 
      Netherlands. j.vanzaane@ggzingeest.nl
FAU - van den Brink, W
AU  - van den Brink W
FAU - Draisma, S
AU  - Draisma S
FAU - Smit, J H
AU  - Smit JH
FAU - Nolen, W A
AU  - Nolen WA
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20100126
PL  - United States
TA  - J Clin Psychiatry
JT  - The Journal of clinical psychiatry
JID - 7801243
SB  - IM
MH  - Adult
MH  - *Affect
MH  - Aged
MH  - Alcohol Drinking/*adverse effects/*epidemiology
MH  - Alcoholism/*epidemiology/rehabilitation
MH  - Bipolar Disorder/*epidemiology/rehabilitation
MH  - Cohort Studies
MH  - Comorbidity
MH  - Cross-Sectional Studies
MH  - Female
MH  - Follow-Up Studies
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Netherlands
MH  - Prospective Studies
MH  - Recurrence
MH  - Sex Factors
MH  - Treatment Outcome
EDAT- 2010/02/04 06:00
MHDA- 2010/08/24 06:00
CRDT- 2010/02/04 06:00
PHST- 2009/01/27 00:00 [received]
PHST- 2009/03/16 00:00 [accepted]
PHST- 2010/02/04 06:00 [entrez]
PHST- 2010/02/04 06:00 [pubmed]
PHST- 2010/08/24 06:00 [medline]
AID - 10.4088/JCP.09m05079gry [doi]
PST - ppublish
SO  - J Clin Psychiatry. 2010 Jul;71(7):885-93. doi: 10.4088/JCP.09m05079gry. Epub 2010 
      Jan 26.