PMID- 20122806
OWN - NLM
STAT- MEDLINE
DCOM- 20100504
LR  - 20100412
IS  - 1532-1967 (Electronic)
IS  - 0305-7372 (Linking)
VI  - 36
IP  - 3
DP  - 2010 May
TI  - Esophagogastric cancer: targeted agents.
PG  - 235-48
LID - 10.1016/j.ctrv.2009.12.009 [doi]
AB  - Because of the poor prognosis for patients with locally advanced and metastatic 
      esophageal, gastroesophageal junction and gastric cancers, increasing attention 
      has focused on the integration of targeted agents into current therapies. The 
      molecular targets of these agents include epidermal growth factor receptor 
      (EGFR), vascular endothelial growth factor (VEGF) or its receptor, 
      cyclooxygenase-2 (COX-2), mammalian target of rapamycin (mTOR) and components and 
      regulators of the cell cycle. In this review article, we briefly discuss 
      pre-clinical data and the rationale for targeting these pathways and summarize 
      the results of clinical trials to-date, including completed and ongoing phase III 
      evaluations.
CI  - Copyright 2009 Elsevier Ltd. All rights reserved.
FAU - Ku, Geoffrey Y
AU  - Ku GY
AD  - Ludwig Center for Cancer Immunotherapy, Department of Medicine, Memorial 
      Sloan-Kettering Cancer Center, New York, NY 10065, USA.
FAU - Ilson, David H
AU  - Ilson DH
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20100201
PL  - Netherlands
TA  - Cancer Treat Rev
JT  - Cancer treatment reviews
JID - 7502030
RN  - 0 (Antineoplastic Agents)
SB  - IM
MH  - Antineoplastic Agents/*therapeutic use
MH  - Clinical Trials as Topic
MH  - Esophageal Neoplasms/*drug therapy
MH  - Humans
MH  - Stomach Neoplasms/*drug therapy
RF  - 178
EDAT- 2010/02/04 06:00
MHDA- 2010/05/05 06:00
CRDT- 2010/02/04 06:00
PHST- 2009/09/23 00:00 [received]
PHST- 2009/12/09 00:00 [revised]
PHST- 2009/12/14 00:00 [accepted]
PHST- 2010/02/04 06:00 [entrez]
PHST- 2010/02/04 06:00 [pubmed]
PHST- 2010/05/05 06:00 [medline]
AID - S0305-7372(09)00191-1 [pii]
AID - 10.1016/j.ctrv.2009.12.009 [doi]
PST - ppublish
SO  - Cancer Treat Rev. 2010 May;36(3):235-48. doi: 10.1016/j.ctrv.2009.12.009. Epub 
      2010 Feb 1.