PMID- 20122829
OWN - NLM
STAT- MEDLINE
DCOM- 20100608
LR  - 20181201
IS  - 1873-2364 (Electronic)
IS  - 0960-8966 (Linking)
VI  - 20
IP  - 3
DP  - 2010 Mar
TI  - Microvasculopathic neuromuscular diseases: lessons from hypoxia-inducible 
      factors.
PG  - 192-7
LID - 10.1016/j.nmd.2010.01.005 [doi]
AB  - Dermatomyositis and vasculitic neuropathies are disorders with immune mediated 
      ischemic injuries. Cellular responses to hypoxia include the hypoxia-inducible 
      factor-1 (HIF-1)-induced transcription of genes involved in angiogenesis. To 
      study their possible roles in those disorders, the immunohistochemical expression 
      of HIF-1alpha, HIF-1beta, HIF-2alpha, vascular endothelial growth factor (VEGF), 
      VEGF-receptor (VEGF-R) and erythropoietin-receptor was investigated. Cases of 
      normal nerves, diabetic neuropathy, normal muscles, polymyositis and 
      inclusion-body-myositis served as controls. The latter were chosen because they 
      represent comparable inflammatory disorders, however, in these ischemia/hypoxia 
      is not supposed to play such a prominent pathogenetic role. Hypoxia-related 
      proteins were not detected in normal controls. In polymyositis and 
      inclusion-body-myositis, there was VEGF-R-expression in muscle fibers and 
      HIF-2alpha reactivity in endothelial cells. In dermatomyositis, HIF-1alpha and 
      HIF-1beta were found in endothelial cells, whereas HIF-2alpha, 
      erythropoietin-receptor, VEGF and VEGF-R additionally were observed in muscle 
      fibers. In vasculitic and diabetic neuropathies, a variable focal expression of 
      hypoxia-inducible factors, VEGF, VEGF-R and erythropoietin-receptor was seen in 
      vessels. These observations suggest that the upregulation of hypoxia-related 
      proteins may represent an adaptation mechanism of neuromuscular tissues to immune 
      mediated deprivation of the blood supply.
CI  - Copyright 2010 Elsevier B.V. All rights reserved.
FAU - Probst-Cousin, Stefan
AU  - Probst-Cousin S
AD  - Department of Neurology, Klinikum Bremen-Ost, Bremen, Germany. 
      stefan.probst@klinikum-bremen-ost.de
FAU - Neundorfer, Bernhard
AU  - Neundorfer B
FAU - Heuss, Dieter
AU  - Heuss D
LA  - eng
PT  - Journal Article
DEP - 20100201
PL  - England
TA  - Neuromuscul Disord
JT  - Neuromuscular disorders : NMD
JID - 9111470
RN  - 0 (Angiogenesis Inducing Agents)
RN  - 0 (Basic Helix-Loop-Helix Transcription Factors)
RN  - 0 (Ephrin-B2)
RN  - 0 (HSP70 Heat-Shock Proteins)
RN  - 0 (Hypoxia-Inducible Factor 1)
RN  - 0 (Proteins)
RN  - 0 (Receptors, Erythropoietin)
RN  - 0 (Vascular Endothelial Growth Factor A)
RN  - 0 (oxygen-regulated proteins)
RN  - 1B37H0967P (endothelial PAS domain-containing protein 1)
RN  - EC 2.7.10.1 (Receptors, Vascular Endothelial Growth Factor)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Angiogenesis Inducing Agents/metabolism
MH  - Basic Helix-Loop-Helix Transcription Factors/metabolism
MH  - Ephrin-B2/metabolism
MH  - Female
MH  - HSP70 Heat-Shock Proteins
MH  - Humans
MH  - Hypoxia-Inducible Factor 1/genetics/*metabolism
MH  - Male
MH  - Microvessels/*metabolism/pathology
MH  - Middle Aged
MH  - Neovascularization, Pathologic/etiology/metabolism
MH  - Neuromuscular Diseases/complications/*metabolism/*pathology
MH  - Proteins/metabolism
MH  - Receptors, Erythropoietin/metabolism
MH  - Receptors, Vascular Endothelial Growth Factor/metabolism
MH  - Up-Regulation/physiology
MH  - Vascular Endothelial Growth Factor A/metabolism
EDAT- 2010/02/04 06:00
MHDA- 2010/06/09 06:00
CRDT- 2010/02/04 06:00
PHST- 2009/09/06 00:00 [received]
PHST- 2009/12/21 00:00 [revised]
PHST- 2010/01/07 00:00 [accepted]
PHST- 2010/02/04 06:00 [entrez]
PHST- 2010/02/04 06:00 [pubmed]
PHST- 2010/06/09 06:00 [medline]
AID - S0960-8966(10)00018-0 [pii]
AID - 10.1016/j.nmd.2010.01.005 [doi]
PST - ppublish
SO  - Neuromuscul Disord. 2010 Mar;20(3):192-7. doi: 10.1016/j.nmd.2010.01.005. Epub 
      2010 Feb 1.