PMID- 20122877
OWN - NLM
STAT- MEDLINE
DCOM- 20100610
LR  - 20211020
IS  - 1556-3871 (Electronic)
IS  - 1547-5271 (Print)
IS  - 1547-5271 (Linking)
VI  - 7
IP  - 4
DP  - 2010 Apr
TI  - Relationship between intended sites of RF ablation and post-procedural scar in AF 
      patients, using late gadolinium enhancement cardiovascular magnetic resonance.
PG  - 489-96
LID - 10.1016/j.hrthm.2009.12.007 [doi]
AB  - BACKGROUND: Radiofrequency (RF) ablation of the left atrium (LA) in patients with 
      atrial fibrillation (AF) is guided by electroanatomic mapping systems. The 
      cardiovascular magnetic resonance (CMR) late gadolinium enhancement (LGE) 
      technique can detect scar after ablation. Direct comparisons between the 
      locations of intended RF ablation sites and locations of scar formation in the LA 
      have not been performed. OBJECTIVE: This study sought to develop and use a method 
      for comparing the sites of RF application with the sites of post-procedural scar 
      formation in the LA. METHODS: A method for rigid registration of CMR LGE images 
      with electroanatomic mapping data (Carto data), visualization of the registered 
      data sets, and quantification of the correlations was developed and used in 19 
      studies of patients with AF. The distance between the Carto points and the CMR LA 
      surface was measured as the mean integration error. The distance between each 
      Carto ablation and the nearest scar was measured. The gaps in sites of LGE and in 
      Carto ablation were also assessed qualitatively, in 6 sectors of each PV. 
      RESULTS: The custom registration method provided a mean integration error between 
      Carto and CMR of 2.7 +/- 0.7 mm. The average distance between Carto and LGE scar 
      was 3.6 +/- 1.3 mm. Qualitatively, 20% of sectors with sites of Carto ablation 
      showed no evidence of LGE. CONCLUSION: There was a visual and quantitative 
      correspondence between Carto ablation sites and LGE scar, but for 20% of Carto 
      ablation sites there was no visible corresponding LGE.
CI  - Copyright 2010 Heart Rhythm Society. Published by Elsevier Inc. All rights 
      reserved.
FAU - Taclas, Jason E
AU  - Taclas JE
AD  - Department of Medicine (Cardiovascular Division), Beth Israel Deaconess Medical 
      Center, Boston, Massachusetts, USA.
FAU - Nezafat, Reza
AU  - Nezafat R
FAU - Wylie, John V
AU  - Wylie JV
FAU - Josephson, Mark E
AU  - Josephson ME
FAU - Hsing, Jeff
AU  - Hsing J
FAU - Manning, Warren J
AU  - Manning WJ
FAU - Peters, Dana C
AU  - Peters DC
LA  - eng
GR  - K01 EB004434/EB/NIBIB NIH HHS/United States
GR  - K01 EB004434-04/EB/NIBIB NIH HHS/United States
GR  - R01 EB008743/EB/NIBIB NIH HHS/United States
GR  - K01 EB004434-01A1/EB/NIBIB NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20091213
PL  - United States
TA  - Heart Rhythm
JT  - Heart rhythm
JID - 101200317
RN  - 0 (Radiopharmaceuticals)
RN  - AU0V1LM3JT (Gadolinium)
SB  - IM
MH  - Aged
MH  - Atrial Fibrillation/*surgery
MH  - Body Surface Potential Mapping
MH  - *Catheter Ablation
MH  - Cicatrix/*diagnostic imaging
MH  - Female
MH  - Gadolinium
MH  - Heart Atria/diagnostic imaging
MH  - Humans
MH  - *Magnetic Resonance Imaging
MH  - Male
MH  - Middle Aged
MH  - Radionuclide Imaging
MH  - Radiopharmaceuticals
PMC - PMC2843771
MID - NIHMS177062
COIS- Conflicts of Interest: Dr. Manning receives research support from Philips 
      Healthcare. Dr. Josephson receives consulting fees from Biosense Webster.
EDAT- 2010/02/04 06:00
MHDA- 2010/06/11 06:00
PMCR- 2011/04/01
CRDT- 2010/02/04 06:00
PHST- 2009/08/21 00:00 [received]
PHST- 2009/12/08 00:00 [accepted]
PHST- 2010/02/04 06:00 [entrez]
PHST- 2010/02/04 06:00 [pubmed]
PHST- 2010/06/11 06:00 [medline]
PHST- 2011/04/01 00:00 [pmc-release]
AID - S1547-5271(09)01378-2 [pii]
AID - 10.1016/j.hrthm.2009.12.007 [doi]
PST - ppublish
SO  - Heart Rhythm. 2010 Apr;7(4):489-96. doi: 10.1016/j.hrthm.2009.12.007. Epub 2009 
      Dec 13.