PMID- 20128236
OWN - NLM
STAT- MEDLINE
DCOM- 20100316
LR  - 20191111
IS  - 0015-5683 (Print)
IS  - 0015-5683 (Linking)
VI  - 56
IP  - 4
DP  - 2009 Dec
TI  - CD4+CD25+Foxp3+ regulatory T cells prevent the development of Th1 immune response 
      by inhibition of dendritic cell function during the early stage of Plasmodium 
      yoelii infection in susceptible BALB/c mice.
PG  - 242-50
AB  - Protective immunity against murine malaria infection depends largely on the 
      establishment of effective Th1 immune response during the early stages of 
      infection. Experimental data suggest that the death of Plasmodium yoelii 17XL (Py 
      17XL) susceptible BALB/c mice results from the suppression of Th1 immune response 
      mediated by CD4+CD25+Foxp3+ regulatory T cells (Tregs). However, the mechanism by 
      which Tregs regulate Th1 immune response is poorly understood. Since immunity is 
      initiated by dendritic cells (DCs), we analysed DC responses to Py 17XL in 
      control and Treg-depleted BALB/c mice. Myeloid DC proliferation, phenotypic 
      maturation and interleukin-12 (IL-12) production were strongly inhibited in 
      control BALB/c mice. In contrast, plasmacytoid DC proliferation and IL-10 
      production were strongly enhanced in control BALB/c mice. In-vivo depletion of 
      Tregs resulted in significantly reversed inhibition of DC response, which may 
      contribute to the establishment of Th1 immune response, indicating that Tregs 
      contribute to the suppression of Th1 immune response during malaria. These 
      findings suggest Tregs contribute to prevent Th1 immune response establishment 
      during the early stage of Py 17XL infection by inhibiting DC response.
FAU - Zheng, Wei
AU  - Zheng W
AD  - Department of Immunology, College of Basic Medical Sciences, China Medical 
      University, Shenyang, China.
FAU - Wang, Qing-Hui
AU  - Wang QH
FAU - Feng, Hui
AU  - Feng H
FAU - Liu, Jun
AU  - Liu J
FAU - Meng, Hong-Rui
AU  - Meng HR
FAU - Cao, Ya-Ming
AU  - Cao YM
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Czech Republic
TA  - Folia Parasitol (Praha)
JT  - Folia parasitologica
JID - 0065750
RN  - 0 (Forkhead Transcription Factors)
RN  - 0 (Foxp3 protein, mouse)
SB  - IM
MH  - Animals
MH  - Dendritic Cells/*physiology
MH  - Female
MH  - Forkhead Transcription Factors/genetics/*metabolism
MH  - Malaria/*immunology/parasitology
MH  - Mice
MH  - Mice, Inbred BALB C
MH  - Plasmodium yoelii
MH  - T-Lymphocytes, Regulatory/*physiology
MH  - Th1 Cells/*physiology
EDAT- 2010/02/05 06:00
MHDA- 2010/03/17 06:00
CRDT- 2010/02/05 06:00
PHST- 2010/02/05 06:00 [entrez]
PHST- 2010/02/05 06:00 [pubmed]
PHST- 2010/03/17 06:00 [medline]
AID - 10.14411/fp.2009.028 [doi]
PST - ppublish
SO  - Folia Parasitol (Praha). 2009 Dec;56(4):242-50. doi: 10.14411/fp.2009.028.