PMID- 20128846
OWN - NLM
STAT- MEDLINE
DCOM- 20110606
LR  - 20161125
IS  - 1460-9568 (Electronic)
IS  - 0953-816X (Linking)
VI  - 30
IP  - 11
DP  - 2009 Dec 3
TI  - Short-term synaptic plasticity at the main and vomeronasal olfactory receptor to 
      mitral cell synapse in frog.
PG  - 2077-88
LID - 10.1111/j.1460-9568.2009.06997.x [doi]
AB  - Synaptic responses resulting from stimulation of the main olfactory and 
      vomeronasal (VN) nerves were measured in main and accessory olfactory bulb (AOB) 
      of frog, Rana pipiens, to test the hypothesis that properties of these synapses 
      would reflect the distinct differences in the time course of odour delivery to 
      each of these olfactory structures. Paired-pulse depression dominated responses 
      to repetitive stimulation of the main olfactory nerve for interstimulus intervals 
      (ISI) up to several seconds. Inhibition of voltage-gated Ca(2+) channels by GABAb 
      receptors contributes significantly to this inhibition of transmitter release, 
      particularly for ISI > 0.5 s. In contrast, the monosynaptic connection between VN 
      sensory neurons and mitral cells in the AOB showed enhancement with pairs or 
      short trains of stimuli for ISI of 0.5 to > 10 s. A small inhibitory effect of 
      GABAb receptors on presynaptic Ca(2+) influx and release was only evident when a 
      large proportion of the VN axons were stimulated simultaneously but even with 
      inhibition present an overall enhancement of release was observed. Increasing the 
      number of conditioning stimuli from one to five increased residual [Ca(2+)] and 
      enhancement but a direct correlation between residual [Ca(2+)] and either the 
      magnitude or the time course of enhancement was not observed. Enhanced 
      transmitter release from VN afferent terminals results in effective integration 
      of sustained low-frequency activity, which may play a role in the detection of 
      low-intensity odourant stimuli by the VN system.
FAU - Delaney, K R
AU  - Delaney KR
AD  - Department of Biology, University of Victoria, Victoria, BC V8W 3N5, Canada. 
      kdelaney@uvic.ca
FAU - Qnais, E Y
AU  - Qnais EY
FAU - Hardy, A B
AU  - Hardy AB
LA  - eng
GR  - MOP 86473/Canadian Institutes of Health Research/Canada
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20091125
PL  - France
TA  - Eur J Neurosci
JT  - The European journal of neuroscience
JID - 8918110
RN  - 0 (Excitatory Amino Acid Agonists)
RN  - 0 (Excitatory Amino Acid Antagonists)
RN  - 0 (GABA Antagonists)
RN  - 0 (Organophosphorus Compounds)
RN  - 87TI61875H (CGP 35348)
RN  - G6D6147J22 (biocytin)
RN  - K3Z4F929H6 (Lysine)
RN  - SY7Q814VUP (Calcium)
RN  - Y37615DVKC (Bicuculline)
SB  - IM
MH  - Animals
MH  - Bicuculline/pharmacology
MH  - Biophysics
MH  - Calcium/metabolism
MH  - Dose-Response Relationship, Drug
MH  - Electric Stimulation/methods
MH  - Excitatory Amino Acid Agonists/pharmacology
MH  - Excitatory Amino Acid Antagonists/pharmacology
MH  - GABA Antagonists/pharmacology
MH  - Lysine/analogs & derivatives/metabolism
MH  - Male
MH  - Neuronal Plasticity/*physiology
MH  - Olfactory Bulb/*cytology
MH  - Olfactory Receptor Neurons/*physiology
MH  - Organophosphorus Compounds/pharmacology
MH  - Patch-Clamp Techniques/methods
MH  - Rana pipiens
MH  - Synapses/*physiology
MH  - Vomeronasal Organ/anatomy & histology/*physiology
EDAT- 2010/02/05 06:00
MHDA- 2011/06/07 06:00
CRDT- 2010/02/05 06:00
PHST- 2010/02/05 06:00 [entrez]
PHST- 2010/02/05 06:00 [pubmed]
PHST- 2011/06/07 06:00 [medline]
AID - EJN6997 [pii]
AID - 10.1111/j.1460-9568.2009.06997.x [doi]
PST - ppublish
SO  - Eur J Neurosci. 2009 Dec 3;30(11):2077-88. doi: 10.1111/j.1460-9568.2009.06997.x. 
      Epub 2009 Nov 25.