PMID- 20131226
OWN - NLM
STAT- MEDLINE
DCOM- 20100402
LR  - 20151119
IS  - 1529-0131 (Electronic)
IS  - 0004-3591 (Linking)
VI  - 62
IP  - 3
DP  - 2010 Mar
TI  - Cardiovascular disease in patients with inflammatory rheumatic disease is 
      associated with up-regulation of markers of inflammation in cardiac microvessels 
      and cardiomyocytes.
PG  - 667-73
LID - 10.1002/art.27264 [doi]
AB  - OBJECTIVE: Various inflammatory rheumatic diseases (IRDs) are associated with 
      increased mortality due to cardiovascular disease. The aim of this study was to 
      investigate heart biopsy specimens obtained from patients undergoing coronary 
      artery bypass grafting and compare markers of inflammation and endothelial cell 
      activation in the cardiac and skeletal muscle of patients with and those without 
      IRD. METHODS: Paired biopsy specimens of cardiac and skeletal muscle were 
      obtained from 22 consecutive patients with IRD and 8 patients without IRD, all of 
      whom were undergoing coronary artery bypass grafting. The biopsy specimens were 
      evaluated in a blinded manner by conventional microscopy and digital image 
      analysis for cell markers (CD3, CD4, CD8, CD68, CD163, and CD31), HLA (HLA-ABC, 
      HLA-DR, and HLA-DQ), adhesion molecules (intercellular adhesion molecule 1 and 
      vascular cell adhesion molecule 1), and proinflammatory cytokines 
      (interleukin-1alpha, interleukin-1beta, and tumor necrosis factor). RESULTS: 
      Patients with IRD had significantly higher expression of adhesion molecules, 
      proinflammatory cytokines, and all classes of HLA on cardiomyocytes and 
      endothelial cells but no increase on mononuclear cells in the myocardium compared 
      with patients without IRD. Furthermore, cardiac muscle from patients with IRD 
      displayed significantly higher local expression of inflammation and activation of 
      cardiac microvessels compared with skeletal muscle from the same patients. 
      CONCLUSION: Patients with cardiovascular disease had increased expression of 
      adhesion molecules, HLA, and proinflammatory cytokines in heart tissue, 
      indicating local inflammation involving microvessels and cardiomyocytes that 
      could play a role in the pathogenesis of cardiovascular disease. The more 
      pronounced changes in patients with IRD compared with patients without IRD might 
      contribute to the increased risk of cardiovascular disease and premature death in 
      patients with IRD.
FAU - Grundtman, Cecilia
AU  - Grundtman C
AD  - Karolinska University Sola, Karolinska Institutet, Stockholm, Sweden.
FAU - Hollan, Ivana
AU  - Hollan I
FAU - Forre, Oystein T
AU  - Forre OT
FAU - Saatvedt, Kjell
AU  - Saatvedt K
FAU - Mikkelsen, Knut
AU  - Mikkelsen K
FAU - Lundberg, Ingrid E
AU  - Lundberg IE
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Arthritis Rheum
JT  - Arthritis and rheumatism
JID - 0370605
RN  - 0 (Biomarkers)
RN  - 0 (Cell Adhesion Molecules)
RN  - 0 (Cytokines)
RN  - 0 (HLA Antigens)
SB  - IM
MH  - Biomarkers/analysis
MH  - Cardiovascular Diseases/*complications/metabolism
MH  - Cell Adhesion Molecules/*analysis
MH  - Cytokines/*analysis
MH  - Female
MH  - HLA Antigens/*analysis
MH  - Humans
MH  - Inflammation/*metabolism
MH  - Male
MH  - Microvessels/*chemistry
MH  - Muscle, Skeletal/chemistry
MH  - Myocytes, Cardiac/*chemistry
MH  - Rheumatic Diseases/*complications/metabolism
MH  - Up-Regulation/physiology
EDAT- 2010/02/05 06:00
MHDA- 2010/04/03 06:00
CRDT- 2010/02/05 06:00
PHST- 2010/02/05 06:00 [entrez]
PHST- 2010/02/05 06:00 [pubmed]
PHST- 2010/04/03 06:00 [medline]
AID - 10.1002/art.27264 [doi]
PST - ppublish
SO  - Arthritis Rheum. 2010 Mar;62(3):667-73. doi: 10.1002/art.27264.