PMID- 20133120
OWN - NLM
STAT- MEDLINE
DCOM- 20110617
LR  - 20110208
IS  - 1873-4022 (Electronic)
IS  - 1873-4022 (Linking)
VI  - 36
IP  - 1
DP  - 2011 Spring
TI  - A case report on the effect of fan beam thickness in helical tomotherapy of 
      nasopharyngeal carcinoma.
PG  - 57-61
LID - 10.1016/j.meddos.2009.11.004 [doi]
AB  - The fan beam thickness (FBT) in helical tomotherapy is defined by a pair of 
      collimators parallel to the rotational orbit of the radiation beam and is fixed 
      for a specific patient treatment. The aim of this case study is to evaluate the 
      dosimetric influence of changing the FBT in the treatment of a nasopharyngeal 
      carcinoma (NPC) patient. The subject was a T2N1M0 stage NPC patient. The planning 
      target volumes (PTVs) of the primary nasopharyngeal tumor and the left and right 
      cervical lymphatics were delineated along with the organs at risk (OARs) in the 
      corresponding computed tomography slices. Three treatment plans with FBT of 1.0 
      cm, 2.5 cm, and 5.0 cm (FBT-10, FBT-25, and FBT-50) were generated separately 
      based on similar dose constraints and planning parameters. The dosimetric results 
      of the PTV and OARs were collected and compared among the 3 treatment plans. The 
      differences in the dose parameters of the PTVs were small among the 3 plans. The 
      FBT-10 plan demonstrated the most homogeneous PTV doses with the smallest 
      homogeneity indices (HIs). The FBT-50 plan delivered the highest dose to the OARs 
      and the FBT-10 plan delivered the lowest. The differences between the 2 plans 
      were more significant in the spinal cord, optic chiasm, optic nerves, and lens. 
      This case study demonstrated that the variation of FBT in tomotherapy affected 
      the quality of the treatment plan mainly in the OAR doses, but not so much in the 
      PTV. Increasing the FBT reduced the effectiveness in the sparing of OARs.
CI  - Copyright (c) 2011 American Association of Medical Dosimetrists. Published by 
      Elsevier Inc. All rights reserved.
FAU - Wu, W C Vincent
AU  - Wu WC
AD  - Department of Health Technology and Informatics, Hong Kong Polytechnic 
      University, Hung Hom, Kowloon, Hong Kong. htvinwu@polyu.edu.hk
FAU - Mui, Wing Lun A
AU  - Mui WL
LA  - eng
PT  - Case Reports
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20100204
PL  - United States
TA  - Med Dosim
JT  - Medical dosimetry : official journal of the American Association of Medical 
      Dosimetrists
JID - 8908862
SB  - IM
MH  - *Algorithms
MH  - Computer Simulation
MH  - Humans
MH  - Models, Biological
MH  - Nasopharyngeal Neoplasms/*radiotherapy
MH  - Radiation Protection/*methods
MH  - Radiometry/*methods
MH  - Radiotherapy Dosage
MH  - Radiotherapy Planning, Computer-Assisted/*methods
MH  - Radiotherapy, Conformal/*methods
EDAT- 2010/02/06 06:00
MHDA- 2011/06/18 06:00
CRDT- 2010/02/06 06:00
PHST- 2009/02/09 00:00 [received]
PHST- 2009/11/13 00:00 [revised]
PHST- 2009/11/24 00:00 [accepted]
PHST- 2010/02/06 06:00 [entrez]
PHST- 2010/02/06 06:00 [pubmed]
PHST- 2011/06/18 06:00 [medline]
AID - S0958-3947(09)00130-7 [pii]
AID - 10.1016/j.meddos.2009.11.004 [doi]
PST - ppublish
SO  - Med Dosim. 2011 Spring;36(1):57-61. doi: 10.1016/j.meddos.2009.11.004. Epub 2010 
      Feb 4.