PMID- 20133860
OWN - NLM
STAT- MEDLINE
DCOM- 20100305
LR  - 20211020
IS  - 1091-6490 (Electronic)
IS  - 0027-8424 (Print)
IS  - 0027-8424 (Linking)
VI  - 107
IP  - 5
DP  - 2010 Feb 2
TI  - bZIP transcription factor zip-2 mediates an early response to Pseudomonas 
      aeruginosa infection in Caenorhabditis elegans.
PG  - 2153-8
LID - 10.1073/pnas.0914643107 [doi]
AB  - Very little is known about how animals discriminate pathogens from innocuous 
      microbes. To address this question, we examined infection-response gene induction 
      in the nematode Caenorhabditis elegans. We focused on genes that are induced in 
      C. elegans by infection with the bacterial pathogen Pseudomonas aeruginosa, but 
      are not induced by an isogenic attenuated gacA mutant. Most of these genes are 
      induced independently of known immunity pathways. We generated a GFP reporter for 
      one of these genes, infection response gene 1 (irg-1), which is induced strongly 
      by wild-type P. aeruginosa strain PA14, but not by other C. elegans pathogens or 
      by other wild-type P. aeruginosa strains that are weakly pathogenic to C. 
      elegans. To identify components of the pathway that induces irg-1 in response to 
      infection, we performed an RNA interference screen of C. elegans transcription 
      factors. This screen identified zip-2, a bZIP transcription factor that is 
      required for inducing irg-1, as well as several other genes, and is important for 
      defense against infection by P. aeruginosa. These data indicate that zip-2 is 
      part of a specialized pathogen response pathway that is induced by virulent 
      strains of P. aeruginosa and provides defense against this pathogen.
FAU - Estes, Kathleen A
AU  - Estes KA
AD  - Division of Biological Sciences, University of California, San Diego, CA 92093, 
      USA.
FAU - Dunbar, Tiffany L
AU  - Dunbar TL
FAU - Powell, Jennifer R
AU  - Powell JR
FAU - Ausubel, Frederick M
AU  - Ausubel FM
FAU - Troemel, Emily R
AU  - Troemel ER
LA  - eng
GR  - P30 DK040561/DK/NIDDK NIH HHS/United States
GR  - P01 AI044220/AI/NIAID NIH HHS/United States
GR  - P30 DK040561-14/DK/NIDDK NIH HHS/United States
GR  - R01 AI064332/AI/NIAID NIH HHS/United States
GR  - R01 AI087528/AI/NIAID NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20100121
PL  - United States
TA  - Proc Natl Acad Sci U S A
JT  - Proceedings of the National Academy of Sciences of the United States of America
JID - 7505876
RN  - 0 (Basic-Leucine Zipper Transcription Factors)
RN  - 0 (Caenorhabditis elegans Proteins)
SB  - IM
MH  - Animals
MH  - Animals, Genetically Modified
MH  - Basic-Leucine Zipper Transcription Factors/antagonists & 
      inhibitors/genetics/*immunology
MH  - Caenorhabditis elegans/genetics/*immunology/*microbiology/physiology
MH  - Caenorhabditis elegans Proteins/antagonists & inhibitors/genetics/*immunology
MH  - Gene Expression
MH  - Genes, Helminth
MH  - MAP Kinase Signaling System
MH  - Models, Immunological
MH  - Pseudomonas aeruginosa/*pathogenicity
MH  - RNA Interference
MH  - Staphylococcus aureus/pathogenicity
MH  - Virulence
PMC - PMC2836710
COIS- The authors declare no conflict of interest.
EDAT- 2010/02/06 06:00
MHDA- 2010/03/06 06:00
PMCR- 2010/08/02
CRDT- 2010/02/06 06:00
PHST- 2010/02/06 06:00 [entrez]
PHST- 2010/02/06 06:00 [pubmed]
PHST- 2010/03/06 06:00 [medline]
PHST- 2010/08/02 00:00 [pmc-release]
AID - 0914643107 [pii]
AID - 200914643 [pii]
AID - 10.1073/pnas.0914643107 [doi]
PST - ppublish
SO  - Proc Natl Acad Sci U S A. 2010 Feb 2;107(5):2153-8. doi: 10.1073/pnas.0914643107. 
      Epub 2010 Jan 21.