PMID- 20134104
OWN - NLM
STAT- MEDLINE
DCOM- 20100401
LR  - 20190923
IS  - 0021-5082 (Print)
IS  - 0021-5082 (Linking)
VI  - 65
IP  - 1
DP  - 2010 Jan
TI  - [Recent development in animal testing to predict the skin and respiratory 
      sensitizing potential of chemicals].
PG  - 14-9
AB  - The identification of chemicals with skin and/or respiratory sensitizing 
      potential is important for the prevention of allergic diseases in both living and 
      work environments. Although a number of animal models for respiratory allergic 
      diseases have been reported, none of these models meets the goals of broad 
      assessments of chemical sensitizing potential. We are attempting to develop a 
      test for predicting the respiratory sensitization of chemicals. In the evaluation 
      of skin sensitization of chemicals, the mostly used predictive tests are the 
      guinea pig maximization test, Buehler test, and mouse local lymph node assay 
      (LLNA). However, only LLNA has been validated formally and independently. Recent 
      studies have revealed that EC3 estimated by LLNA correlates well with human skin 
      sensitizing potency and the threshold for the induction of skin sensitization in 
      the human repeat patch test. Thus, LLNA can predict the potency of skin 
      sensitizing potential of a chemical and its risk in humans.
FAU - Aoyama, Kohji
AU  - Aoyama K
AD  - Department of Environmental Medicine, Graduate School of Medical and Dental 
      Sciences, Kagoshima University, Kagoshima, Japan. aoyama@m.kufm.kagoshima-u.ac.jp
LA  - jpn
PT  - English Abstract
PT  - Journal Article
PT  - Review
PL  - Japan
TA  - Nihon Eiseigaku Zasshi
JT  - Nihon eiseigaku zasshi. Japanese journal of hygiene
JID - 0417457
RN  - 17X7AFZ1GH (Toluene 2,4-Diisocyanate)
RN  - 958-74-7 (methylthymidine)
RN  - VC2W18DGKR (Thymidine)
SB  - IM
MH  - *Animal Experimentation
MH  - Animals
MH  - Bronchial Provocation Tests/*methods
MH  - Guinea Pigs
MH  - Humans
MH  - Hypersensitivity/prevention & control
MH  - Local Lymph Node Assay
MH  - Mice
MH  - Patch Tests/*methods
MH  - Predictive Value of Tests
MH  - Risk Assessment/methods
MH  - Thymidine/adverse effects/analogs & derivatives/immunology
MH  - Toluene 2,4-Diisocyanate/adverse effects/immunology
RF  - 48
EDAT- 2010/02/06 06:00
MHDA- 2010/04/02 06:00
CRDT- 2010/02/06 06:00
PHST- 2010/02/06 06:00 [entrez]
PHST- 2010/02/06 06:00 [pubmed]
PHST- 2010/04/02 06:00 [medline]
AID - JST.JSTAGE/jjh/65.14 [pii]
AID - 10.1265/jjh.65.14 [doi]
PST - ppublish
SO  - Nihon Eiseigaku Zasshi. 2010 Jan;65(1):14-9. doi: 10.1265/jjh.65.14.