PMID- 20134155
OWN - NLM
STAT- MEDLINE
DCOM- 20100419
LR  - 20100401
IS  - 1421-9662 (Electronic)
IS  - 0001-5792 (Linking)
VI  - 123
IP  - 3
DP  - 2010
TI  - Heparin-induced thrombocytopenia in patients with Philadelphia-negative 
      myeloproliferative disorders and unusual splanchnic or cerebral vein thrombosis.
PG  - 140-5
LID - 10.1159/000280466 [doi]
AB  - BACKGROUND: Philadelphia-negative myeloproliferative disorders (Ph-MPD) are 
      common causes of unusual splanchnic or cerebral vein thrombosis, which is treated 
      with unfractionated heparin (UFH) or low-molecular-weight heparin (LMWH). 
      Heparin-induced thrombocytopenia (HIT) is a dangerous potential complication of 
      this therapy, but it has rarely been reported in Ph-MPD. PATIENTS AND METHODS: We 
      retrospectively reviewed clinical records of 29 patients with Ph-MPD who have 
      been treated with UFH or LMWH for unusual splanchnic or cerebral vein thrombosis 
      (3 cerebral sinus, 6 portal and 20 hepatic vein). The goal of the study was to 
      determine the occurrence of new thrombotic events during heparin therapy 
      secondary to HIT (HITT). RESULTS: During heparin therapy, 5 out of the 29 
      patients (17%) developed a new thrombotic episode (pulmonary embolism) with a 
      high clinical probability of HIT based on the 4 T's score even though not all the 
      patients developed 'true' thrombocytopenia. A diagnosis of HIT was established in 
      2 patients (6.8%) through the presence of heparin-related antibodies. 
      CONCLUSIONS: Ph-MPD patients on heparin warrant careful monitoring and HIT has to 
      be suspected whenever platelet counts drop or a new thrombosis is detectable.
FAU - Randi, Maria L
AU  - Randi ML
AD  - Department of Medical and Surgical Sciences, University of Padua Medical School, 
      Padua, Italy.
FAU - Tezza, Fabiana
AU  - Tezza F
FAU - Scapin, Margherita
AU  - Scapin M
FAU - Duner, Elena
AU  - Duner E
FAU - Scarparo, Pamela
AU  - Scarparo P
FAU - Scandellari, Raffaella
AU  - Scandellari R
FAU - Fabris, Fabrizio
AU  - Fabris F
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20100204
PL  - Switzerland
TA  - Acta Haematol
JT  - Acta haematologica
JID - 0141053
RN  - 0 (Anticoagulants)
RN  - 0 (Heparin, Low-Molecular-Weight)
RN  - 9005-49-6 (Heparin)
SB  - IM
MH  - Adult
MH  - Anticoagulants/*adverse effects/immunology/therapeutic use
MH  - Budd-Chiari Syndrome/complications/drug therapy
MH  - Drug Monitoring
MH  - Female
MH  - Heparin/*adverse effects/immunology/therapeutic use
MH  - Heparin, Low-Molecular-Weight/adverse effects/immunology/therapeutic use
MH  - Humans
MH  - Intracranial Thrombosis/complications/drug therapy
MH  - Male
MH  - Middle Aged
MH  - Myeloproliferative Disorders/*complications
MH  - Platelet Count
MH  - Polycythemia Vera/complications
MH  - Pulmonary Embolism/*epidemiology/etiology/prevention & control
MH  - Retrospective Studies
MH  - Thrombocythemia, Essential/complications
MH  - Thrombocytopenia/*chemically induced/etiology/immunology
MH  - Thrombosis/complications/*drug therapy
MH  - Time Factors
MH  - Young Adult
EDAT- 2010/02/06 06:00
MHDA- 2010/04/20 06:00
CRDT- 2010/02/06 06:00
PHST- 2009/11/23 00:00 [received]
PHST- 2009/12/07 00:00 [accepted]
PHST- 2010/02/06 06:00 [entrez]
PHST- 2010/02/06 06:00 [pubmed]
PHST- 2010/04/20 06:00 [medline]
AID - 000280466 [pii]
AID - 10.1159/000280466 [doi]
PST - ppublish
SO  - Acta Haematol. 2010;123(3):140-5. doi: 10.1159/000280466. Epub 2010 Feb 4.