PMID- 20134257
OWN - NLM
STAT- MEDLINE
DCOM- 20100421
LR  - 20221207
IS  - 1720-8386 (Electronic)
IS  - 0391-4097 (Linking)
VI  - 32
IP  - 11
DP  - 2009 Dec
TI  - Intensive insulin therapy reduces the urinary intercellular adhesion molecule-1 
      excretion in patients with Type 2 diabetes mellitus.
PG  - 877-80
AB  - OBJECTIVE: To observe the change of urinary intercellular adhesion molecule-1 
      (ICAM-1) excretion in the patients with Type 2 diabetes mellitus (T2DM) compared 
      to normal control group, and to investigate the effect and significance of 
      insulin intensive therapy on the urinary ICAM-1 excretion. METHOD: We examined 
      the urinary ICAM-1 and creatinine (Cr) of random urine in 20 patients with T2DM 
      and 20 normal subjects using enzyme-linked immunosorbent assay. All diabetics 
      were given intensive insulin therapy for 2 weeks, urinary ICAM- 1 and Cr was 
      examined once again at the end of observation. RESULTS: Compared with the normal 
      control group, not only the fasting blood glucose (FBG), post-prandial 2-h blood 
      glucose (P2hBG), and glycosylated hemoglobin (HbA1c), but also the urinary ICAM-1 
      to urinary Cr ratio in patients with T2DM increased significantly (p<0.01). The 
      urinary ICAM-1/urinary Cr ratio of diabetics had a positive correlation with FBG 
      (r=0.51, p<0.01), P2hBG (r=0.496, p<0.01), and HbA1c (r=0.478, p<0.05), 
      respectively. After 2 weeks of intensive insulin therapy in Type 2 diabetics, 
      both the level of blood glucose and the level of urinary ICAM-1/urinary Cr ratio 
      had a remarkable decrease compared with the basal values (p<0.01). CONCLUSION: 
      Intensive insulin therapy is capable of alleviating the enhanced local 
      inflammation reaction of renal tissue under hyperglycemia state with the 
      reduction of urinary ICAM-1 excretion.
FAU - Sun, Z
AU  - Sun Z
AD  - Department of Endocrinology, Anhui Provincal Hospital affiliated to Anhui Medical 
      University, No.17 Lujiang Road, Hefei, Anhui, 230001, PR China.
FAU - Ye, S
AU  - Ye S
FAU - Qian, Y
AU  - Qian Y
FAU - Sui, L
AU  - Sui L
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Italy
TA  - J Endocrinol Invest
JT  - Journal of endocrinological investigation
JID - 7806594
RN  - 0 (Blood Glucose)
RN  - 0 (Glycated Hemoglobin A)
RN  - 0 (Insulin)
RN  - 0 (hemoglobin A1c protein, human)
RN  - 126547-89-5 (Intercellular Adhesion Molecule-1)
RN  - AYI8EX34EU (Creatinine)
SB  - IM
MH  - Adult
MH  - Blood Glucose/metabolism
MH  - Creatinine/urine
MH  - Diabetes Mellitus, Type 2/*drug therapy/*urine
MH  - Female
MH  - Glycated Hemoglobin/metabolism
MH  - Humans
MH  - Insulin/therapeutic use
MH  - Intercellular Adhesion Molecule-1/*urine
MH  - Male
MH  - Middle Aged
EDAT- 2010/02/06 06:00
MHDA- 2010/04/22 06:00
CRDT- 2010/02/06 06:00
PHST- 2010/02/06 06:00 [entrez]
PHST- 2010/02/06 06:00 [pubmed]
PHST- 2010/04/22 06:00 [medline]
AID - 6802 [pii]
AID - 10.1007/BF03345765 [doi]
PST - ppublish
SO  - J Endocrinol Invest. 2009 Dec;32(11):877-80. doi: 10.1007/BF03345765.